Iclaprim reduces the incidence and severity of Staphylococcus aureus-induced septic arthritis in a murine model

Staphylococcus aureus is the most common non-gonococcal aetiology of septic arthritis. The efficacy of iclaprim against S. aureus LS-1, a clinical strain identified from a patient with septic arthritis, was studied in MF1 mice to evaluate the activity of iclaprim, which is in clinical development, i...

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Detalles Bibliográficos
Autores principales: Huang, D. B., Noviello, S., Gemmell, C. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Microbiology Society 2019
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7481738/
https://www.ncbi.nlm.nih.gov/pubmed/32974543
http://dx.doi.org/10.1099/acmi.0.000052
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author Huang, D. B.
Noviello, S.
Gemmell, C. G.
author_facet Huang, D. B.
Noviello, S.
Gemmell, C. G.
author_sort Huang, D. B.
collection PubMed
description Staphylococcus aureus is the most common non-gonococcal aetiology of septic arthritis. The efficacy of iclaprim against S. aureus LS-1, a clinical strain identified from a patient with septic arthritis, was studied in MF1 mice to evaluate the activity of iclaprim, which is in clinical development, in preventing joint infections. Iclaprim (2.5–80 mg kg(−) (1)) administered as a single dose via the tail vein reduced the incidence of S. aureus septic arthritis and mortality in an experimental murine model of septic arthritis.
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spelling pubmed-74817382020-09-23 Iclaprim reduces the incidence and severity of Staphylococcus aureus-induced septic arthritis in a murine model Huang, D. B. Noviello, S. Gemmell, C. G. Access Microbiol Short Communication Staphylococcus aureus is the most common non-gonococcal aetiology of septic arthritis. The efficacy of iclaprim against S. aureus LS-1, a clinical strain identified from a patient with septic arthritis, was studied in MF1 mice to evaluate the activity of iclaprim, which is in clinical development, in preventing joint infections. Iclaprim (2.5–80 mg kg(−) (1)) administered as a single dose via the tail vein reduced the incidence of S. aureus septic arthritis and mortality in an experimental murine model of septic arthritis. Microbiology Society 2019-08-20 /pmc/articles/PMC7481738/ /pubmed/32974543 http://dx.doi.org/10.1099/acmi.0.000052 Text en © 2019 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License.
spellingShingle Short Communication
Huang, D. B.
Noviello, S.
Gemmell, C. G.
Iclaprim reduces the incidence and severity of Staphylococcus aureus-induced septic arthritis in a murine model
title Iclaprim reduces the incidence and severity of Staphylococcus aureus-induced septic arthritis in a murine model
title_full Iclaprim reduces the incidence and severity of Staphylococcus aureus-induced septic arthritis in a murine model
title_fullStr Iclaprim reduces the incidence and severity of Staphylococcus aureus-induced septic arthritis in a murine model
title_full_unstemmed Iclaprim reduces the incidence and severity of Staphylococcus aureus-induced septic arthritis in a murine model
title_short Iclaprim reduces the incidence and severity of Staphylococcus aureus-induced septic arthritis in a murine model
title_sort iclaprim reduces the incidence and severity of staphylococcus aureus-induced septic arthritis in a murine model
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7481738/
https://www.ncbi.nlm.nih.gov/pubmed/32974543
http://dx.doi.org/10.1099/acmi.0.000052
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