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Drug reaction with eosinophilia and systemic symptoms (DRESS) with severe and atypical lung involvement

Drug reaction with eosinophilia and systemic symptoms is a rare and potentially fatal drug hypersensitivity reaction. Reactions include skin eruption, fever, hematologic abnormalities (eosinophilia or atypical lymphocytosis), enlarged lymph nodes, and/or organic involvement. The liver is the most co...

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Autores principales: Guerrero Gómez, Diego Armando, París Zorro, Sara, Aponte Barrios, Wilmer, Carrillo Bayona, Jorge Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7481882/
https://www.ncbi.nlm.nih.gov/pubmed/32944113
http://dx.doi.org/10.1016/j.radcr.2020.08.037
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author Guerrero Gómez, Diego Armando
París Zorro, Sara
Aponte Barrios, Wilmer
Carrillo Bayona, Jorge Alberto
author_facet Guerrero Gómez, Diego Armando
París Zorro, Sara
Aponte Barrios, Wilmer
Carrillo Bayona, Jorge Alberto
author_sort Guerrero Gómez, Diego Armando
collection PubMed
description Drug reaction with eosinophilia and systemic symptoms is a rare and potentially fatal drug hypersensitivity reaction. Reactions include skin eruption, fever, hematologic abnormalities (eosinophilia or atypical lymphocytosis), enlarged lymph nodes, and/or organic involvement. The liver is the most commonly compromised organ. We present a case of drug reaction with eosinophilia and systemic symptoms associated with Naproxen intake in a young female patient with severe lung involvement. The patient's chest tomography highlights the presence of adenomegalies, pericardial and pleural effusion, peribroncovascular consolidations, and centrilobular nodules. After reviewing the literature few similar cases were found. The main radiological alterations in those cases included interstitial opacities attributed to pneumonitis. Therefore, this case study is considered an unusual case with atypical presentation of drug-induced eosinophilic lung disease.
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spelling pubmed-74818822020-09-16 Drug reaction with eosinophilia and systemic symptoms (DRESS) with severe and atypical lung involvement Guerrero Gómez, Diego Armando París Zorro, Sara Aponte Barrios, Wilmer Carrillo Bayona, Jorge Alberto Radiol Case Rep Case Report Drug reaction with eosinophilia and systemic symptoms is a rare and potentially fatal drug hypersensitivity reaction. Reactions include skin eruption, fever, hematologic abnormalities (eosinophilia or atypical lymphocytosis), enlarged lymph nodes, and/or organic involvement. The liver is the most commonly compromised organ. We present a case of drug reaction with eosinophilia and systemic symptoms associated with Naproxen intake in a young female patient with severe lung involvement. The patient's chest tomography highlights the presence of adenomegalies, pericardial and pleural effusion, peribroncovascular consolidations, and centrilobular nodules. After reviewing the literature few similar cases were found. The main radiological alterations in those cases included interstitial opacities attributed to pneumonitis. Therefore, this case study is considered an unusual case with atypical presentation of drug-induced eosinophilic lung disease. Elsevier 2020-09-04 /pmc/articles/PMC7481882/ /pubmed/32944113 http://dx.doi.org/10.1016/j.radcr.2020.08.037 Text en © 2020 The Authors. Published by Elsevier Inc. on behalf of University of Washington. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Guerrero Gómez, Diego Armando
París Zorro, Sara
Aponte Barrios, Wilmer
Carrillo Bayona, Jorge Alberto
Drug reaction with eosinophilia and systemic symptoms (DRESS) with severe and atypical lung involvement
title Drug reaction with eosinophilia and systemic symptoms (DRESS) with severe and atypical lung involvement
title_full Drug reaction with eosinophilia and systemic symptoms (DRESS) with severe and atypical lung involvement
title_fullStr Drug reaction with eosinophilia and systemic symptoms (DRESS) with severe and atypical lung involvement
title_full_unstemmed Drug reaction with eosinophilia and systemic symptoms (DRESS) with severe and atypical lung involvement
title_short Drug reaction with eosinophilia and systemic symptoms (DRESS) with severe and atypical lung involvement
title_sort drug reaction with eosinophilia and systemic symptoms (dress) with severe and atypical lung involvement
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7481882/
https://www.ncbi.nlm.nih.gov/pubmed/32944113
http://dx.doi.org/10.1016/j.radcr.2020.08.037
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