Cargando…
The Polygenic and Monogenic Basis of Blood Traits and Diseases
Blood cells play essential roles in human health, underpinning physiological processes such as immunity, oxygen transport, and clotting, which when perturbed cause a significant global health burden. Here we integrate data from UK Biobank and a large-scale international collaborative effort, includi...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cell Press
2020
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7482360/ https://www.ncbi.nlm.nih.gov/pubmed/32888494 http://dx.doi.org/10.1016/j.cell.2020.08.008 |
| _version_ | 1783580776192802816 |
|---|---|
| author | Vuckovic, Dragana Bao, Erik L. Akbari, Parsa Lareau, Caleb A. Mousas, Abdou Jiang, Tao Chen, Ming-Huei Raffield, Laura M. Tardaguila, Manuel Huffman, Jennifer E. Ritchie, Scott C. Megy, Karyn Ponstingl, Hannes Penkett, Christopher J. Albers, Patrick K. Wigdor, Emilie M. Sakaue, Saori Moscati, Arden Manansala, Regina Lo, Ken Sin Qian, Huijun Akiyama, Masato Bartz, Traci M. Ben-Shlomo, Yoav Beswick, Andrew Bork-Jensen, Jette Bottinger, Erwin P. Brody, Jennifer A. van Rooij, Frank J.A. Chitrala, Kumaraswamy N. Wilson, Peter W.F. Choquet, Hélène Danesh, John Di Angelantonio, Emanuele Dimou, Niki Ding, Jingzhong Elliott, Paul Esko, Tõnu Evans, Michele K. Felix, Stephan B. Floyd, James S. Broer, Linda Grarup, Niels Guo, Michael H. Guo, Qi Greinacher, Andreas Haessler, Jeff Hansen, Torben Howson, Joanna M.M. Huang, Wei Jorgenson, Eric Kacprowski, Tim Kähönen, Mika Kamatani, Yoichiro Kanai, Masahiro Karthikeyan, Savita Koskeridis, Fotios Lange, Leslie A. Lehtimäki, Terho Linneberg, Allan Liu, Yongmei Lyytikäinen, Leo-Pekka Manichaikul, Ani Matsuda, Koichi Mohlke, Karen L. Mononen, Nina Murakami, Yoshinori Nadkarni, Girish N. Nikus, Kjell Pankratz, Nathan Pedersen, Oluf Preuss, Michael Psaty, Bruce M. Raitakari, Olli T. Rich, Stephen S. Rodriguez, Benjamin A.T. Rosen, Jonathan D. Rotter, Jerome I. Schubert, Petra Spracklen, Cassandra N. Surendran, Praveen Tang, Hua Tardif, Jean-Claude Ghanbari, Mohsen Völker, Uwe Völzke, Henry Watkins, Nicholas A. Weiss, Stefan Cai, Na Kundu, Kousik Watt, Stephen B. Walter, Klaudia Zonderman, Alan B. Cho, Kelly Li, Yun Loos, Ruth J.F. Knight, Julian C. Georges, Michel Stegle, Oliver Evangelou, Evangelos Okada, Yukinori Roberts, David J. Inouye, Michael Johnson, Andrew D. Auer, Paul L. Astle, William J. Reiner, Alexander P. Butterworth, Adam S. Ouwehand, Willem H. Lettre, Guillaume Sankaran, Vijay G. Soranzo, Nicole |
| author_facet | Vuckovic, Dragana Bao, Erik L. Akbari, Parsa Lareau, Caleb A. Mousas, Abdou Jiang, Tao Chen, Ming-Huei Raffield, Laura M. Tardaguila, Manuel Huffman, Jennifer E. Ritchie, Scott C. Megy, Karyn Ponstingl, Hannes Penkett, Christopher J. Albers, Patrick K. Wigdor, Emilie M. Sakaue, Saori Moscati, Arden Manansala, Regina Lo, Ken Sin Qian, Huijun Akiyama, Masato Bartz, Traci M. Ben-Shlomo, Yoav Beswick, Andrew Bork-Jensen, Jette Bottinger, Erwin P. Brody, Jennifer A. van Rooij, Frank J.A. Chitrala, Kumaraswamy N. Wilson, Peter W.F. Choquet, Hélène Danesh, John Di Angelantonio, Emanuele Dimou, Niki Ding, Jingzhong Elliott, Paul Esko, Tõnu Evans, Michele K. Felix, Stephan B. Floyd, James S. Broer, Linda Grarup, Niels Guo, Michael H. Guo, Qi Greinacher, Andreas Haessler, Jeff Hansen, Torben Howson, Joanna M.M. Huang, Wei Jorgenson, Eric Kacprowski, Tim Kähönen, Mika Kamatani, Yoichiro Kanai, Masahiro Karthikeyan, Savita Koskeridis, Fotios Lange, Leslie A. Lehtimäki, Terho Linneberg, Allan Liu, Yongmei Lyytikäinen, Leo-Pekka Manichaikul, Ani Matsuda, Koichi Mohlke, Karen L. Mononen, Nina Murakami, Yoshinori Nadkarni, Girish N. Nikus, Kjell Pankratz, Nathan Pedersen, Oluf Preuss, Michael Psaty, Bruce M. Raitakari, Olli T. Rich, Stephen S. Rodriguez, Benjamin A.T. Rosen, Jonathan D. Rotter, Jerome I. Schubert, Petra Spracklen, Cassandra N. Surendran, Praveen Tang, Hua Tardif, Jean-Claude Ghanbari, Mohsen Völker, Uwe Völzke, Henry Watkins, Nicholas A. Weiss, Stefan Cai, Na Kundu, Kousik Watt, Stephen B. Walter, Klaudia Zonderman, Alan B. Cho, Kelly Li, Yun Loos, Ruth J.F. Knight, Julian C. Georges, Michel Stegle, Oliver Evangelou, Evangelos Okada, Yukinori Roberts, David J. Inouye, Michael Johnson, Andrew D. Auer, Paul L. Astle, William J. Reiner, Alexander P. Butterworth, Adam S. Ouwehand, Willem H. Lettre, Guillaume Sankaran, Vijay G. Soranzo, Nicole |
| author_sort | Vuckovic, Dragana |
| collection | PubMed |
| description | Blood cells play essential roles in human health, underpinning physiological processes such as immunity, oxygen transport, and clotting, which when perturbed cause a significant global health burden. Here we integrate data from UK Biobank and a large-scale international collaborative effort, including data for 563,085 European ancestry participants, and discover 5,106 new genetic variants independently associated with 29 blood cell phenotypes covering a range of variation impacting hematopoiesis. We holistically characterize the genetic architecture of hematopoiesis, assess the relevance of the omnigenic model to blood cell phenotypes, delineate relevant hematopoietic cell states influenced by regulatory genetic variants and gene networks, identify novel splice-altering variants mediating the associations, and assess the polygenic prediction potential for blood traits and clinical disorders at the interface of complex and Mendelian genetics. These results show the power of large-scale blood cell trait GWAS to interrogate clinically meaningful variants across a wide allelic spectrum of human variation. |
| format | Online Article Text |
| id | pubmed-7482360 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | Cell Press |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-74823602020-09-17 The Polygenic and Monogenic Basis of Blood Traits and Diseases Vuckovic, Dragana Bao, Erik L. Akbari, Parsa Lareau, Caleb A. Mousas, Abdou Jiang, Tao Chen, Ming-Huei Raffield, Laura M. Tardaguila, Manuel Huffman, Jennifer E. Ritchie, Scott C. Megy, Karyn Ponstingl, Hannes Penkett, Christopher J. Albers, Patrick K. Wigdor, Emilie M. Sakaue, Saori Moscati, Arden Manansala, Regina Lo, Ken Sin Qian, Huijun Akiyama, Masato Bartz, Traci M. Ben-Shlomo, Yoav Beswick, Andrew Bork-Jensen, Jette Bottinger, Erwin P. Brody, Jennifer A. van Rooij, Frank J.A. Chitrala, Kumaraswamy N. Wilson, Peter W.F. Choquet, Hélène Danesh, John Di Angelantonio, Emanuele Dimou, Niki Ding, Jingzhong Elliott, Paul Esko, Tõnu Evans, Michele K. Felix, Stephan B. Floyd, James S. Broer, Linda Grarup, Niels Guo, Michael H. Guo, Qi Greinacher, Andreas Haessler, Jeff Hansen, Torben Howson, Joanna M.M. Huang, Wei Jorgenson, Eric Kacprowski, Tim Kähönen, Mika Kamatani, Yoichiro Kanai, Masahiro Karthikeyan, Savita Koskeridis, Fotios Lange, Leslie A. Lehtimäki, Terho Linneberg, Allan Liu, Yongmei Lyytikäinen, Leo-Pekka Manichaikul, Ani Matsuda, Koichi Mohlke, Karen L. Mononen, Nina Murakami, Yoshinori Nadkarni, Girish N. Nikus, Kjell Pankratz, Nathan Pedersen, Oluf Preuss, Michael Psaty, Bruce M. Raitakari, Olli T. Rich, Stephen S. Rodriguez, Benjamin A.T. Rosen, Jonathan D. Rotter, Jerome I. Schubert, Petra Spracklen, Cassandra N. Surendran, Praveen Tang, Hua Tardif, Jean-Claude Ghanbari, Mohsen Völker, Uwe Völzke, Henry Watkins, Nicholas A. Weiss, Stefan Cai, Na Kundu, Kousik Watt, Stephen B. Walter, Klaudia Zonderman, Alan B. Cho, Kelly Li, Yun Loos, Ruth J.F. Knight, Julian C. Georges, Michel Stegle, Oliver Evangelou, Evangelos Okada, Yukinori Roberts, David J. Inouye, Michael Johnson, Andrew D. Auer, Paul L. Astle, William J. Reiner, Alexander P. Butterworth, Adam S. Ouwehand, Willem H. Lettre, Guillaume Sankaran, Vijay G. Soranzo, Nicole Cell Article Blood cells play essential roles in human health, underpinning physiological processes such as immunity, oxygen transport, and clotting, which when perturbed cause a significant global health burden. Here we integrate data from UK Biobank and a large-scale international collaborative effort, including data for 563,085 European ancestry participants, and discover 5,106 new genetic variants independently associated with 29 blood cell phenotypes covering a range of variation impacting hematopoiesis. We holistically characterize the genetic architecture of hematopoiesis, assess the relevance of the omnigenic model to blood cell phenotypes, delineate relevant hematopoietic cell states influenced by regulatory genetic variants and gene networks, identify novel splice-altering variants mediating the associations, and assess the polygenic prediction potential for blood traits and clinical disorders at the interface of complex and Mendelian genetics. These results show the power of large-scale blood cell trait GWAS to interrogate clinically meaningful variants across a wide allelic spectrum of human variation. Cell Press 2020-09-03 /pmc/articles/PMC7482360/ /pubmed/32888494 http://dx.doi.org/10.1016/j.cell.2020.08.008 Text en © 2020 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| spellingShingle | Article Vuckovic, Dragana Bao, Erik L. Akbari, Parsa Lareau, Caleb A. Mousas, Abdou Jiang, Tao Chen, Ming-Huei Raffield, Laura M. Tardaguila, Manuel Huffman, Jennifer E. Ritchie, Scott C. Megy, Karyn Ponstingl, Hannes Penkett, Christopher J. Albers, Patrick K. Wigdor, Emilie M. Sakaue, Saori Moscati, Arden Manansala, Regina Lo, Ken Sin Qian, Huijun Akiyama, Masato Bartz, Traci M. Ben-Shlomo, Yoav Beswick, Andrew Bork-Jensen, Jette Bottinger, Erwin P. Brody, Jennifer A. van Rooij, Frank J.A. Chitrala, Kumaraswamy N. Wilson, Peter W.F. Choquet, Hélène Danesh, John Di Angelantonio, Emanuele Dimou, Niki Ding, Jingzhong Elliott, Paul Esko, Tõnu Evans, Michele K. Felix, Stephan B. Floyd, James S. Broer, Linda Grarup, Niels Guo, Michael H. Guo, Qi Greinacher, Andreas Haessler, Jeff Hansen, Torben Howson, Joanna M.M. Huang, Wei Jorgenson, Eric Kacprowski, Tim Kähönen, Mika Kamatani, Yoichiro Kanai, Masahiro Karthikeyan, Savita Koskeridis, Fotios Lange, Leslie A. Lehtimäki, Terho Linneberg, Allan Liu, Yongmei Lyytikäinen, Leo-Pekka Manichaikul, Ani Matsuda, Koichi Mohlke, Karen L. Mononen, Nina Murakami, Yoshinori Nadkarni, Girish N. Nikus, Kjell Pankratz, Nathan Pedersen, Oluf Preuss, Michael Psaty, Bruce M. Raitakari, Olli T. Rich, Stephen S. Rodriguez, Benjamin A.T. Rosen, Jonathan D. Rotter, Jerome I. Schubert, Petra Spracklen, Cassandra N. Surendran, Praveen Tang, Hua Tardif, Jean-Claude Ghanbari, Mohsen Völker, Uwe Völzke, Henry Watkins, Nicholas A. Weiss, Stefan Cai, Na Kundu, Kousik Watt, Stephen B. Walter, Klaudia Zonderman, Alan B. Cho, Kelly Li, Yun Loos, Ruth J.F. Knight, Julian C. Georges, Michel Stegle, Oliver Evangelou, Evangelos Okada, Yukinori Roberts, David J. Inouye, Michael Johnson, Andrew D. Auer, Paul L. Astle, William J. Reiner, Alexander P. Butterworth, Adam S. Ouwehand, Willem H. Lettre, Guillaume Sankaran, Vijay G. Soranzo, Nicole The Polygenic and Monogenic Basis of Blood Traits and Diseases |
| title | The Polygenic and Monogenic Basis of Blood Traits and Diseases |
| title_full | The Polygenic and Monogenic Basis of Blood Traits and Diseases |
| title_fullStr | The Polygenic and Monogenic Basis of Blood Traits and Diseases |
| title_full_unstemmed | The Polygenic and Monogenic Basis of Blood Traits and Diseases |
| title_short | The Polygenic and Monogenic Basis of Blood Traits and Diseases |
| title_sort | polygenic and monogenic basis of blood traits and diseases |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7482360/ https://www.ncbi.nlm.nih.gov/pubmed/32888494 http://dx.doi.org/10.1016/j.cell.2020.08.008 |
| work_keys_str_mv | AT vuckovicdragana thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT baoerikl thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT akbariparsa thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT lareaucaleba thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT mousasabdou thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT jiangtao thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT chenminghuei thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT raffieldlauram thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT tardaguilamanuel thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT huffmanjennifere thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT ritchiescottc thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT megykaryn thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT ponstinglhannes thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT penkettchristopherj thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT alberspatrickk thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT wigdoremiliem thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT sakauesaori thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT moscatiarden thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT manansalaregina thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT lokensin thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT qianhuijun thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT akiyamamasato thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT bartztracim thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT benshlomoyoav thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT beswickandrew thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT borkjensenjette thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT bottingererwinp thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT brodyjennifera thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT vanrooijfrankja thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT chitralakumaraswamyn thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT wilsonpeterwf thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT choquethelene thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT daneshjohn thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT diangelantonioemanuele thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT dimouniki thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT dingjingzhong thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT elliottpaul thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT eskotonu thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT evansmichelek thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT felixstephanb thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT floydjamess thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT broerlinda thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT grarupniels thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT guomichaelh thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT guoqi thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT greinacherandreas thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT haesslerjeff thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT hansentorben thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT howsonjoannamm thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT huangwei thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT jorgensoneric thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT kacprowskitim thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT kahonenmika thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT kamataniyoichiro thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT kanaimasahiro thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT karthikeyansavita thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT koskeridisfotios thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT langelesliea thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT lehtimakiterho thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT linnebergallan thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT liuyongmei thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT lyytikainenleopekka thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT manichaikulani thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT matsudakoichi thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT mohlkekarenl thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT mononennina thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT murakamiyoshinori thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT nadkarnigirishn thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT nikuskjell thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT pankratznathan thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT pedersenoluf thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT preussmichael thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT psatybrucem thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT raitakariollit thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT richstephens thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT rodriguezbenjaminat thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT rosenjonathand thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT rotterjeromei thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT schubertpetra thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT spracklencassandran thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT surendranpraveen thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT tanghua thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT tardifjeanclaude thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT ghanbarimohsen thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT volkeruwe thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT volzkehenry thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT watkinsnicholasa thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT weissstefan thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT caina thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT kundukousik thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT wattstephenb thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT walterklaudia thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT zondermanalanb thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT chokelly thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT liyun thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT loosruthjf thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT knightjulianc thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT georgesmichel thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT stegleoliver thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT evangelouevangelos thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT okadayukinori thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT robertsdavidj thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT inouyemichael thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT johnsonandrewd thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT auerpaull thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT astlewilliamj thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT reineralexanderp thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT butterworthadams thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT ouwehandwillemh thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT lettreguillaume thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT sankaranvijayg thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT soranzonicole thepolygenicandmonogenicbasisofbloodtraitsanddiseases AT vuckovicdragana polygenicandmonogenicbasisofbloodtraitsanddiseases AT baoerikl polygenicandmonogenicbasisofbloodtraitsanddiseases AT akbariparsa polygenicandmonogenicbasisofbloodtraitsanddiseases AT lareaucaleba polygenicandmonogenicbasisofbloodtraitsanddiseases AT mousasabdou polygenicandmonogenicbasisofbloodtraitsanddiseases AT jiangtao polygenicandmonogenicbasisofbloodtraitsanddiseases AT chenminghuei polygenicandmonogenicbasisofbloodtraitsanddiseases AT raffieldlauram polygenicandmonogenicbasisofbloodtraitsanddiseases AT tardaguilamanuel polygenicandmonogenicbasisofbloodtraitsanddiseases AT huffmanjennifere polygenicandmonogenicbasisofbloodtraitsanddiseases AT ritchiescottc polygenicandmonogenicbasisofbloodtraitsanddiseases AT megykaryn polygenicandmonogenicbasisofbloodtraitsanddiseases AT ponstinglhannes polygenicandmonogenicbasisofbloodtraitsanddiseases AT penkettchristopherj polygenicandmonogenicbasisofbloodtraitsanddiseases AT alberspatrickk polygenicandmonogenicbasisofbloodtraitsanddiseases AT wigdoremiliem polygenicandmonogenicbasisofbloodtraitsanddiseases AT sakauesaori polygenicandmonogenicbasisofbloodtraitsanddiseases AT moscatiarden polygenicandmonogenicbasisofbloodtraitsanddiseases AT manansalaregina polygenicandmonogenicbasisofbloodtraitsanddiseases AT lokensin polygenicandmonogenicbasisofbloodtraitsanddiseases AT qianhuijun polygenicandmonogenicbasisofbloodtraitsanddiseases AT akiyamamasato polygenicandmonogenicbasisofbloodtraitsanddiseases AT bartztracim polygenicandmonogenicbasisofbloodtraitsanddiseases AT benshlomoyoav polygenicandmonogenicbasisofbloodtraitsanddiseases AT beswickandrew polygenicandmonogenicbasisofbloodtraitsanddiseases AT borkjensenjette polygenicandmonogenicbasisofbloodtraitsanddiseases AT bottingererwinp polygenicandmonogenicbasisofbloodtraitsanddiseases AT brodyjennifera polygenicandmonogenicbasisofbloodtraitsanddiseases AT vanrooijfrankja polygenicandmonogenicbasisofbloodtraitsanddiseases AT chitralakumaraswamyn polygenicandmonogenicbasisofbloodtraitsanddiseases AT wilsonpeterwf polygenicandmonogenicbasisofbloodtraitsanddiseases AT choquethelene polygenicandmonogenicbasisofbloodtraitsanddiseases AT daneshjohn polygenicandmonogenicbasisofbloodtraitsanddiseases AT diangelantonioemanuele polygenicandmonogenicbasisofbloodtraitsanddiseases AT dimouniki polygenicandmonogenicbasisofbloodtraitsanddiseases AT dingjingzhong polygenicandmonogenicbasisofbloodtraitsanddiseases AT elliottpaul polygenicandmonogenicbasisofbloodtraitsanddiseases AT eskotonu polygenicandmonogenicbasisofbloodtraitsanddiseases AT evansmichelek polygenicandmonogenicbasisofbloodtraitsanddiseases AT felixstephanb polygenicandmonogenicbasisofbloodtraitsanddiseases AT floydjamess polygenicandmonogenicbasisofbloodtraitsanddiseases AT broerlinda polygenicandmonogenicbasisofbloodtraitsanddiseases AT grarupniels polygenicandmonogenicbasisofbloodtraitsanddiseases AT guomichaelh polygenicandmonogenicbasisofbloodtraitsanddiseases AT guoqi polygenicandmonogenicbasisofbloodtraitsanddiseases AT greinacherandreas polygenicandmonogenicbasisofbloodtraitsanddiseases AT haesslerjeff polygenicandmonogenicbasisofbloodtraitsanddiseases AT hansentorben polygenicandmonogenicbasisofbloodtraitsanddiseases AT howsonjoannamm polygenicandmonogenicbasisofbloodtraitsanddiseases AT huangwei polygenicandmonogenicbasisofbloodtraitsanddiseases AT jorgensoneric polygenicandmonogenicbasisofbloodtraitsanddiseases AT kacprowskitim polygenicandmonogenicbasisofbloodtraitsanddiseases AT kahonenmika polygenicandmonogenicbasisofbloodtraitsanddiseases AT kamataniyoichiro polygenicandmonogenicbasisofbloodtraitsanddiseases AT kanaimasahiro polygenicandmonogenicbasisofbloodtraitsanddiseases AT karthikeyansavita polygenicandmonogenicbasisofbloodtraitsanddiseases AT koskeridisfotios polygenicandmonogenicbasisofbloodtraitsanddiseases AT langelesliea polygenicandmonogenicbasisofbloodtraitsanddiseases AT lehtimakiterho polygenicandmonogenicbasisofbloodtraitsanddiseases AT linnebergallan polygenicandmonogenicbasisofbloodtraitsanddiseases AT liuyongmei polygenicandmonogenicbasisofbloodtraitsanddiseases AT lyytikainenleopekka polygenicandmonogenicbasisofbloodtraitsanddiseases AT manichaikulani polygenicandmonogenicbasisofbloodtraitsanddiseases AT matsudakoichi polygenicandmonogenicbasisofbloodtraitsanddiseases AT mohlkekarenl polygenicandmonogenicbasisofbloodtraitsanddiseases AT mononennina polygenicandmonogenicbasisofbloodtraitsanddiseases AT murakamiyoshinori polygenicandmonogenicbasisofbloodtraitsanddiseases AT nadkarnigirishn polygenicandmonogenicbasisofbloodtraitsanddiseases AT nikuskjell polygenicandmonogenicbasisofbloodtraitsanddiseases AT pankratznathan polygenicandmonogenicbasisofbloodtraitsanddiseases AT pedersenoluf polygenicandmonogenicbasisofbloodtraitsanddiseases AT preussmichael polygenicandmonogenicbasisofbloodtraitsanddiseases AT psatybrucem polygenicandmonogenicbasisofbloodtraitsanddiseases AT raitakariollit polygenicandmonogenicbasisofbloodtraitsanddiseases AT richstephens polygenicandmonogenicbasisofbloodtraitsanddiseases AT rodriguezbenjaminat polygenicandmonogenicbasisofbloodtraitsanddiseases AT rosenjonathand polygenicandmonogenicbasisofbloodtraitsanddiseases AT rotterjeromei polygenicandmonogenicbasisofbloodtraitsanddiseases AT schubertpetra polygenicandmonogenicbasisofbloodtraitsanddiseases AT spracklencassandran polygenicandmonogenicbasisofbloodtraitsanddiseases AT surendranpraveen polygenicandmonogenicbasisofbloodtraitsanddiseases AT tanghua polygenicandmonogenicbasisofbloodtraitsanddiseases AT tardifjeanclaude polygenicandmonogenicbasisofbloodtraitsanddiseases AT ghanbarimohsen polygenicandmonogenicbasisofbloodtraitsanddiseases AT volkeruwe polygenicandmonogenicbasisofbloodtraitsanddiseases AT volzkehenry polygenicandmonogenicbasisofbloodtraitsanddiseases AT watkinsnicholasa polygenicandmonogenicbasisofbloodtraitsanddiseases AT weissstefan polygenicandmonogenicbasisofbloodtraitsanddiseases AT polygenicandmonogenicbasisofbloodtraitsanddiseases AT caina polygenicandmonogenicbasisofbloodtraitsanddiseases AT kundukousik polygenicandmonogenicbasisofbloodtraitsanddiseases AT wattstephenb polygenicandmonogenicbasisofbloodtraitsanddiseases AT walterklaudia polygenicandmonogenicbasisofbloodtraitsanddiseases AT zondermanalanb polygenicandmonogenicbasisofbloodtraitsanddiseases AT chokelly polygenicandmonogenicbasisofbloodtraitsanddiseases AT liyun polygenicandmonogenicbasisofbloodtraitsanddiseases AT loosruthjf polygenicandmonogenicbasisofbloodtraitsanddiseases AT knightjulianc polygenicandmonogenicbasisofbloodtraitsanddiseases AT georgesmichel polygenicandmonogenicbasisofbloodtraitsanddiseases AT stegleoliver polygenicandmonogenicbasisofbloodtraitsanddiseases AT evangelouevangelos polygenicandmonogenicbasisofbloodtraitsanddiseases AT okadayukinori polygenicandmonogenicbasisofbloodtraitsanddiseases AT robertsdavidj polygenicandmonogenicbasisofbloodtraitsanddiseases AT inouyemichael polygenicandmonogenicbasisofbloodtraitsanddiseases AT johnsonandrewd polygenicandmonogenicbasisofbloodtraitsanddiseases AT auerpaull polygenicandmonogenicbasisofbloodtraitsanddiseases AT astlewilliamj polygenicandmonogenicbasisofbloodtraitsanddiseases AT reineralexanderp polygenicandmonogenicbasisofbloodtraitsanddiseases AT butterworthadams polygenicandmonogenicbasisofbloodtraitsanddiseases AT ouwehandwillemh polygenicandmonogenicbasisofbloodtraitsanddiseases AT lettreguillaume polygenicandmonogenicbasisofbloodtraitsanddiseases AT sankaranvijayg polygenicandmonogenicbasisofbloodtraitsanddiseases AT soranzonicole polygenicandmonogenicbasisofbloodtraitsanddiseases |