Comparison of four commercial SARS-CoV-2 IgG immuno-assays in RT-PCR negative patients with suspect CT findings

A subset of patients with Covid-19 presents with negative RT-PCR screening but suspect CT findings. Using four commercially available anti-SARS-CoV-2 IgG immuno-assays, we found this subset constituted 9.2% of all consecutively admitted outpatients with Covid-19 in our hospital. Clinical specificity...

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Autores principales: Van Praet, Jens T., Coene, Ann-Sofie, Van De Moortele, Kris, Descheemaeker, Patrick, Reynders, Marijke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7482374/
https://www.ncbi.nlm.nih.gov/pubmed/32910322
http://dx.doi.org/10.1007/s15010-020-01523-3
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author Van Praet, Jens T.
Coene, Ann-Sofie
Van De Moortele, Kris
Descheemaeker, Patrick
Reynders, Marijke
author_facet Van Praet, Jens T.
Coene, Ann-Sofie
Van De Moortele, Kris
Descheemaeker, Patrick
Reynders, Marijke
author_sort Van Praet, Jens T.
collection PubMed
description A subset of patients with Covid-19 presents with negative RT-PCR screening but suspect CT findings. Using four commercially available anti-SARS-CoV-2 IgG immuno-assays, we found this subset constituted 9.2% of all consecutively admitted outpatients with Covid-19 in our hospital. Clinical specificity for Covid-19 of some N protein-based immuno-assays was suboptimal, as positive results were observed in control patients with recent common human coronavirus, influenza B and adenovirus infections. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s15010-020-01523-3) contains supplementary material, which is available to authorized users.
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spelling pubmed-74823742020-09-10 Comparison of four commercial SARS-CoV-2 IgG immuno-assays in RT-PCR negative patients with suspect CT findings Van Praet, Jens T. Coene, Ann-Sofie Van De Moortele, Kris Descheemaeker, Patrick Reynders, Marijke Infection Brief Report A subset of patients with Covid-19 presents with negative RT-PCR screening but suspect CT findings. Using four commercially available anti-SARS-CoV-2 IgG immuno-assays, we found this subset constituted 9.2% of all consecutively admitted outpatients with Covid-19 in our hospital. Clinical specificity for Covid-19 of some N protein-based immuno-assays was suboptimal, as positive results were observed in control patients with recent common human coronavirus, influenza B and adenovirus infections. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s15010-020-01523-3) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2020-09-10 2021 /pmc/articles/PMC7482374/ /pubmed/32910322 http://dx.doi.org/10.1007/s15010-020-01523-3 Text en © Springer-Verlag GmbH Germany, part of Springer Nature 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Brief Report
Van Praet, Jens T.
Coene, Ann-Sofie
Van De Moortele, Kris
Descheemaeker, Patrick
Reynders, Marijke
Comparison of four commercial SARS-CoV-2 IgG immuno-assays in RT-PCR negative patients with suspect CT findings
title Comparison of four commercial SARS-CoV-2 IgG immuno-assays in RT-PCR negative patients with suspect CT findings
title_full Comparison of four commercial SARS-CoV-2 IgG immuno-assays in RT-PCR negative patients with suspect CT findings
title_fullStr Comparison of four commercial SARS-CoV-2 IgG immuno-assays in RT-PCR negative patients with suspect CT findings
title_full_unstemmed Comparison of four commercial SARS-CoV-2 IgG immuno-assays in RT-PCR negative patients with suspect CT findings
title_short Comparison of four commercial SARS-CoV-2 IgG immuno-assays in RT-PCR negative patients with suspect CT findings
title_sort comparison of four commercial sars-cov-2 igg immuno-assays in rt-pcr negative patients with suspect ct findings
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7482374/
https://www.ncbi.nlm.nih.gov/pubmed/32910322
http://dx.doi.org/10.1007/s15010-020-01523-3
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