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Pharmacokinetic Modeling of [(18)F]MC225 for Quantification of the P-Glycoprotein Function at the Blood–Brain Barrier in Non-Human Primates with PET

[Image: see text] [(18)F]MC225 has been developed as a weak substrate of P-glycoprotein (P-gp) aimed to measure changes in the P-gp function at the blood–brain barrier with positron emission tomography. This study evaluates [(18)F]MC225 kinetics in non-human primates and investigates the effect of b...

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Detalles Bibliográficos
Autores principales:	García-Varela, Lara, Arif, Wejdan M., Vállez García, David, Kakiuchi, Takeharu, Ohba, Hiroyuki, Harada, Norihiro, Tago, Tetsuro, Elsinga, Philip H., Tsukada, Hideo, Colabufo, Nicola Antonio, Dierckx, Rudi A. J. O., van Waarde, Aren, Toyohara, Jun, Boellaard, Ronald, Luurtsema, Gert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2020
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7482398/ https://www.ncbi.nlm.nih.gov/pubmed/32787277 http://dx.doi.org/10.1021/acs.molpharmaceut.0c00514

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