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The flavonoid agathisflavone modulates the microglial neuroinflammatory response and enhances remyelination
Myelin loss is the hallmark of the demyelinating disease multiple sclerosis (MS) and plays a significant role in multiple neurodegenerative diseases. A common factor in all neuropathologies is the central role of microglia, the intrinsic immune cells of the central nervous system (CNS). Microglia ar...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7482432/ https://www.ncbi.nlm.nih.gov/pubmed/32534098 http://dx.doi.org/10.1016/j.phrs.2020.104997 |
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author | de Almeida, Monique Marylin Alves Pieropan, Francesca de Mattos Oliveira, Larissa dos Santos Junior, Manoelito Coelho David, Jorge Mauricio David, Juceni Pereira da Silva, Victor Diógenes A. dos Santos Souza, Cleide Costa, Silvia Lima Butt, Arthur Morgan |
author_facet | de Almeida, Monique Marylin Alves Pieropan, Francesca de Mattos Oliveira, Larissa dos Santos Junior, Manoelito Coelho David, Jorge Mauricio David, Juceni Pereira da Silva, Victor Diógenes A. dos Santos Souza, Cleide Costa, Silvia Lima Butt, Arthur Morgan |
author_sort | de Almeida, Monique Marylin Alves |
collection | PubMed |
description | Myelin loss is the hallmark of the demyelinating disease multiple sclerosis (MS) and plays a significant role in multiple neurodegenerative diseases. A common factor in all neuropathologies is the central role of microglia, the intrinsic immune cells of the central nervous system (CNS). Microglia are activated in pathology and can have both pro- and anti-inflammatory functions. Here, we examined the effects of the flavonoid agathisflavone on microglia and remyelination in the cerebellar slice model following lysolecithin induced demyelination. Notably, agathisflavone enhances remyelination and alters microglial activation state, as determined by their morphology and cytokine profile. Furthermore, these effects of agathisflavone on remyelination and microglial activation were inhibited by blockade of estrogen receptor α. Thus, our results identify agathisflavone as a novel compound that may act via ER to regulate microglial activation and enhance remyelination and repair. |
format | Online Article Text |
id | pubmed-7482432 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-74824322020-09-17 The flavonoid agathisflavone modulates the microglial neuroinflammatory response and enhances remyelination de Almeida, Monique Marylin Alves Pieropan, Francesca de Mattos Oliveira, Larissa dos Santos Junior, Manoelito Coelho David, Jorge Mauricio David, Juceni Pereira da Silva, Victor Diógenes A. dos Santos Souza, Cleide Costa, Silvia Lima Butt, Arthur Morgan Pharmacol Res Article Myelin loss is the hallmark of the demyelinating disease multiple sclerosis (MS) and plays a significant role in multiple neurodegenerative diseases. A common factor in all neuropathologies is the central role of microglia, the intrinsic immune cells of the central nervous system (CNS). Microglia are activated in pathology and can have both pro- and anti-inflammatory functions. Here, we examined the effects of the flavonoid agathisflavone on microglia and remyelination in the cerebellar slice model following lysolecithin induced demyelination. Notably, agathisflavone enhances remyelination and alters microglial activation state, as determined by their morphology and cytokine profile. Furthermore, these effects of agathisflavone on remyelination and microglial activation were inhibited by blockade of estrogen receptor α. Thus, our results identify agathisflavone as a novel compound that may act via ER to regulate microglial activation and enhance remyelination and repair. Elsevier 2020-09 /pmc/articles/PMC7482432/ /pubmed/32534098 http://dx.doi.org/10.1016/j.phrs.2020.104997 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article de Almeida, Monique Marylin Alves Pieropan, Francesca de Mattos Oliveira, Larissa dos Santos Junior, Manoelito Coelho David, Jorge Mauricio David, Juceni Pereira da Silva, Victor Diógenes A. dos Santos Souza, Cleide Costa, Silvia Lima Butt, Arthur Morgan The flavonoid agathisflavone modulates the microglial neuroinflammatory response and enhances remyelination |
title | The flavonoid agathisflavone modulates the microglial neuroinflammatory response and enhances remyelination |
title_full | The flavonoid agathisflavone modulates the microglial neuroinflammatory response and enhances remyelination |
title_fullStr | The flavonoid agathisflavone modulates the microglial neuroinflammatory response and enhances remyelination |
title_full_unstemmed | The flavonoid agathisflavone modulates the microglial neuroinflammatory response and enhances remyelination |
title_short | The flavonoid agathisflavone modulates the microglial neuroinflammatory response and enhances remyelination |
title_sort | flavonoid agathisflavone modulates the microglial neuroinflammatory response and enhances remyelination |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7482432/ https://www.ncbi.nlm.nih.gov/pubmed/32534098 http://dx.doi.org/10.1016/j.phrs.2020.104997 |
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