Cargando…

Decrease in Choroidal Vascularity Index of Haller’s layer in diabetic eyes precedes retinopathy

INTRODUCTION: The study aimed to evaluate Choroidal Vascularity Index (CVI) of Haller’s and Sattler’s layers and their relationships with choroidal and retinal thickness, volumes measured on enhanced depth imaging–optical coherence tomography (OCT) scans in the eyes of patients without diabetes, pat...

Descripción completa

Detalles Bibliográficos
Autores principales: Foo, Valencia Hui Xian, Gupta, Preeti, Nguyen, Quang Duc, Chong, Crystal Chun Yuen, Agrawal, Rupesh, Cheng, Ching-Yu, Yanagi, Yasuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7482468/
https://www.ncbi.nlm.nih.gov/pubmed/32912848
http://dx.doi.org/10.1136/bmjdrc-2020-001295
_version_ 1783580792649154560
author Foo, Valencia Hui Xian
Gupta, Preeti
Nguyen, Quang Duc
Chong, Crystal Chun Yuen
Agrawal, Rupesh
Cheng, Ching-Yu
Yanagi, Yasuo
author_facet Foo, Valencia Hui Xian
Gupta, Preeti
Nguyen, Quang Duc
Chong, Crystal Chun Yuen
Agrawal, Rupesh
Cheng, Ching-Yu
Yanagi, Yasuo
author_sort Foo, Valencia Hui Xian
collection PubMed
description INTRODUCTION: The study aimed to evaluate Choroidal Vascularity Index (CVI) of Haller’s and Sattler’s layers and their relationships with choroidal and retinal thickness, volumes measured on enhanced depth imaging–optical coherence tomography (OCT) scans in the eyes of patients without diabetes, patients with diabetes with no diabetic retinopathy (DR) and patients with diabetes and DR. RESEARCH DESIGN AND METHODS: Retrospective analysis of 165 eyes from 84 Singapore Indian Eye Study-2 study participants (group 1: no diabetes, group 2: diabetes with no DR and group 3: with DR). Groups 1 and 2 were matched by age and gender from group 3. RESULTS: In the eyes of patients with diabetes without DR, the macular CVI of Haller’s but not Sattler’s layer was significantly reduced compared with eyes of patients without diabetes. Eyes with >5 years of diabetes have significantly decreased CVI of Sattler’s layers (mean difference=0.06 ± 0.10, p=0.04) and also decreased subfoveal choroidal volume (mean difference=0.89 ± 0.16 mm(3), p=0.02), compared with those with ≤5 years of diabetes. CONCLUSION: Diabetic eyes without DR had significantly lower CVI of macular Haller’s layer than those of healthy controls. With a longer duration of diabetes, CVI of subfoveal Sattler’s layer and choroidal volume continue to decrease, irrespective of diabetic control, suggesting that early diabetic choroidopathy mainly affects larger choroidal veins initially before medium-sized arterioles. The CVI of macular Haller’s layer could potentially be used as a marker on spectral domain OCT imaging in newly diagnosed patients with diabetes for the onset of DR and as a possible prognostication tool in diabetic eyes. Future prospective longitudinal studies in diabetic eyes would be useful in establishing the relationship between CVIs of Haller’s and Sattler’s layer with visual acuity as a marker of photoreceptor health and visual prognosis.
format Online
Article
Text
id pubmed-7482468
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher BMJ Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-74824682020-09-18 Decrease in Choroidal Vascularity Index of Haller’s layer in diabetic eyes precedes retinopathy Foo, Valencia Hui Xian Gupta, Preeti Nguyen, Quang Duc Chong, Crystal Chun Yuen Agrawal, Rupesh Cheng, Ching-Yu Yanagi, Yasuo BMJ Open Diabetes Res Care Pathophysiology/Complications INTRODUCTION: The study aimed to evaluate Choroidal Vascularity Index (CVI) of Haller’s and Sattler’s layers and their relationships with choroidal and retinal thickness, volumes measured on enhanced depth imaging–optical coherence tomography (OCT) scans in the eyes of patients without diabetes, patients with diabetes with no diabetic retinopathy (DR) and patients with diabetes and DR. RESEARCH DESIGN AND METHODS: Retrospective analysis of 165 eyes from 84 Singapore Indian Eye Study-2 study participants (group 1: no diabetes, group 2: diabetes with no DR and group 3: with DR). Groups 1 and 2 were matched by age and gender from group 3. RESULTS: In the eyes of patients with diabetes without DR, the macular CVI of Haller’s but not Sattler’s layer was significantly reduced compared with eyes of patients without diabetes. Eyes with >5 years of diabetes have significantly decreased CVI of Sattler’s layers (mean difference=0.06 ± 0.10, p=0.04) and also decreased subfoveal choroidal volume (mean difference=0.89 ± 0.16 mm(3), p=0.02), compared with those with ≤5 years of diabetes. CONCLUSION: Diabetic eyes without DR had significantly lower CVI of macular Haller’s layer than those of healthy controls. With a longer duration of diabetes, CVI of subfoveal Sattler’s layer and choroidal volume continue to decrease, irrespective of diabetic control, suggesting that early diabetic choroidopathy mainly affects larger choroidal veins initially before medium-sized arterioles. The CVI of macular Haller’s layer could potentially be used as a marker on spectral domain OCT imaging in newly diagnosed patients with diabetes for the onset of DR and as a possible prognostication tool in diabetic eyes. Future prospective longitudinal studies in diabetic eyes would be useful in establishing the relationship between CVIs of Haller’s and Sattler’s layer with visual acuity as a marker of photoreceptor health and visual prognosis. BMJ Publishing Group 2020-09-09 /pmc/articles/PMC7482468/ /pubmed/32912848 http://dx.doi.org/10.1136/bmjdrc-2020-001295 Text en © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/ http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Pathophysiology/Complications
Foo, Valencia Hui Xian
Gupta, Preeti
Nguyen, Quang Duc
Chong, Crystal Chun Yuen
Agrawal, Rupesh
Cheng, Ching-Yu
Yanagi, Yasuo
Decrease in Choroidal Vascularity Index of Haller’s layer in diabetic eyes precedes retinopathy
title Decrease in Choroidal Vascularity Index of Haller’s layer in diabetic eyes precedes retinopathy
title_full Decrease in Choroidal Vascularity Index of Haller’s layer in diabetic eyes precedes retinopathy
title_fullStr Decrease in Choroidal Vascularity Index of Haller’s layer in diabetic eyes precedes retinopathy
title_full_unstemmed Decrease in Choroidal Vascularity Index of Haller’s layer in diabetic eyes precedes retinopathy
title_short Decrease in Choroidal Vascularity Index of Haller’s layer in diabetic eyes precedes retinopathy
title_sort decrease in choroidal vascularity index of haller’s layer in diabetic eyes precedes retinopathy
topic Pathophysiology/Complications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7482468/
https://www.ncbi.nlm.nih.gov/pubmed/32912848
http://dx.doi.org/10.1136/bmjdrc-2020-001295
work_keys_str_mv AT foovalenciahuixian decreaseinchoroidalvascularityindexofhallerslayerindiabeticeyesprecedesretinopathy
AT guptapreeti decreaseinchoroidalvascularityindexofhallerslayerindiabeticeyesprecedesretinopathy
AT nguyenquangduc decreaseinchoroidalvascularityindexofhallerslayerindiabeticeyesprecedesretinopathy
AT chongcrystalchunyuen decreaseinchoroidalvascularityindexofhallerslayerindiabeticeyesprecedesretinopathy
AT agrawalrupesh decreaseinchoroidalvascularityindexofhallerslayerindiabeticeyesprecedesretinopathy
AT chengchingyu decreaseinchoroidalvascularityindexofhallerslayerindiabeticeyesprecedesretinopathy
AT yanagiyasuo decreaseinchoroidalvascularityindexofhallerslayerindiabeticeyesprecedesretinopathy