Germline PALB2 Mutations in Cancers and Its Distinction From Somatic PALB2 Mutations in Breast Cancers

PALB2 is an important BRCAx candidate for familial breast cancers (FBC). PALB2 pathogenic variants (PVs) may not to conform to “two hit” paradigm. However, a recent study demonstrates that in the majority PALB2 germline mutant breast cancers, the loss of heterozygosity (LOH) and somatic point mutati...

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Detalles Bibliográficos
Autores principales: Hu, Zhe-Yu, Liu, Liping, Xie, Ning, Lu, Jun, Liu, Zhentian, Tang, Yu, Wang, Yikai, Yang, Jianbo, Ouyang, Quchang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7482549/
https://www.ncbi.nlm.nih.gov/pubmed/33193564
http://dx.doi.org/10.3389/fgene.2020.00829

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