Cargando…
AAV-Delivered Tulp1 Supplementation Therapy Targeting Photoreceptors Provides Minimal Benefit in Tulp1−/− Retinas
With marketing approval of the first ocular gene therapy, and other gene therapies in clinical trial, treatments for inherited retinal degenerations (IRDs) have become a reality. Biallelic mutations in the tubby like protein 1 gene (TULP1) are causative of IRDs in humans; a mouse knock-out model (Tu...
Autores principales: | Palfi, Arpad, Yesmambetov, Adlet, Millington-Ward, Sophia, Shortall, Ciara, Humphries, Pete, Kenna, Paul F., Chadderton, Naomi, Farrar, G. Jane |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7482550/ https://www.ncbi.nlm.nih.gov/pubmed/32973439 http://dx.doi.org/10.3389/fnins.2020.00891 |
Ejemplares similares
-
Non-photoreceptor Expression of Tulp1 May Contribute to Extensive Retinal Degeneration in Tulp1-/- Mice
por: Palfi, Arpad, et al.
Publicado: (2020) -
Photoreceptor Compartment-Specific TULP1 Interactomes
por: Ebke, Lindsey A., et al.
Publicado: (2021) -
AAV-PHP.eB transduces both the inner and outer retina with high efficacy in mice
por: Palfi, Arpad, et al.
Publicado: (2022) -
Efficient gene delivery to photoreceptors using AAV2/rh10 and rescue of the Rho(–/–) mouse
por: Palfi, Arpad, et al.
Publicado: (2015) -
Corrigendum to “Efficient gene delivery to photoreceptors using AAV2/rh10 and rescue of the Rho–/– mouse”
por: Palfi, Arpad, et al.
Publicado: (2016)