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Assessment of surface roughness and blood rheology on local coronary haemodynamics: a multi-scale computational fluid dynamics study

The surface roughness of the coronary artery is associated with the onset of atherosclerosis. The study applies, for the first time, the micro-scale variation of the artery surface to a 3D coronary model, investigating the impact on haemodynamic parameters which are indicators for atherosclerosis. T...

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Detalles Bibliográficos
Autores principales: Owen, David G., Schenkel, Torsten, Shepherd, Duncan E. T., Espino, Daniel M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7482556/
https://www.ncbi.nlm.nih.gov/pubmed/32781935
http://dx.doi.org/10.1098/rsif.2020.0327
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author Owen, David G.
Schenkel, Torsten
Shepherd, Duncan E. T.
Espino, Daniel M.
author_facet Owen, David G.
Schenkel, Torsten
Shepherd, Duncan E. T.
Espino, Daniel M.
author_sort Owen, David G.
collection PubMed
description The surface roughness of the coronary artery is associated with the onset of atherosclerosis. The study applies, for the first time, the micro-scale variation of the artery surface to a 3D coronary model, investigating the impact on haemodynamic parameters which are indicators for atherosclerosis. The surface roughness of porcine coronary arteries have been detailed based on optical microscopy and implemented into a cylindrical section of coronary artery. Several approaches to rheology are compared to determine the benefits/limitations of both single and multiphase models for multi-scale geometry. Haemodynamic parameters averaged over the rough/smooth sections are similar; however, the rough surface experiences a much wider range, with maximum wall shear stress greater than 6 Pa compared to the approximately 3 Pa on the smooth segment. This suggests the smooth-walled assumption may neglect important near-wall haemodynamics. While rheological models lack sufficient definition to truly encompass the micro-scale effects occurring over the rough surface, single-phase models (Newtonian and non-Newtonian) provide numerically stable and comparable results to other coronary simulations. Multiphase models allow for phase interactions between plasma and red blood cells which is more suited to such multi-scale models. These models require additional physical laws to govern advection/aggregation of particulates in the near-wall region.
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spelling pubmed-74825562020-09-18 Assessment of surface roughness and blood rheology on local coronary haemodynamics: a multi-scale computational fluid dynamics study Owen, David G. Schenkel, Torsten Shepherd, Duncan E. T. Espino, Daniel M. J R Soc Interface Life Sciences–Engineering interface The surface roughness of the coronary artery is associated with the onset of atherosclerosis. The study applies, for the first time, the micro-scale variation of the artery surface to a 3D coronary model, investigating the impact on haemodynamic parameters which are indicators for atherosclerosis. The surface roughness of porcine coronary arteries have been detailed based on optical microscopy and implemented into a cylindrical section of coronary artery. Several approaches to rheology are compared to determine the benefits/limitations of both single and multiphase models for multi-scale geometry. Haemodynamic parameters averaged over the rough/smooth sections are similar; however, the rough surface experiences a much wider range, with maximum wall shear stress greater than 6 Pa compared to the approximately 3 Pa on the smooth segment. This suggests the smooth-walled assumption may neglect important near-wall haemodynamics. While rheological models lack sufficient definition to truly encompass the micro-scale effects occurring over the rough surface, single-phase models (Newtonian and non-Newtonian) provide numerically stable and comparable results to other coronary simulations. Multiphase models allow for phase interactions between plasma and red blood cells which is more suited to such multi-scale models. These models require additional physical laws to govern advection/aggregation of particulates in the near-wall region. The Royal Society 2020-08 2020-08-12 /pmc/articles/PMC7482556/ /pubmed/32781935 http://dx.doi.org/10.1098/rsif.2020.0327 Text en © 2020 The Authors. http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/http://creativecommons.org/licenses/by/4.0/Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
spellingShingle Life Sciences–Engineering interface
Owen, David G.
Schenkel, Torsten
Shepherd, Duncan E. T.
Espino, Daniel M.
Assessment of surface roughness and blood rheology on local coronary haemodynamics: a multi-scale computational fluid dynamics study
title Assessment of surface roughness and blood rheology on local coronary haemodynamics: a multi-scale computational fluid dynamics study
title_full Assessment of surface roughness and blood rheology on local coronary haemodynamics: a multi-scale computational fluid dynamics study
title_fullStr Assessment of surface roughness and blood rheology on local coronary haemodynamics: a multi-scale computational fluid dynamics study
title_full_unstemmed Assessment of surface roughness and blood rheology on local coronary haemodynamics: a multi-scale computational fluid dynamics study
title_short Assessment of surface roughness and blood rheology on local coronary haemodynamics: a multi-scale computational fluid dynamics study
title_sort assessment of surface roughness and blood rheology on local coronary haemodynamics: a multi-scale computational fluid dynamics study
topic Life Sciences–Engineering interface
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7482556/
https://www.ncbi.nlm.nih.gov/pubmed/32781935
http://dx.doi.org/10.1098/rsif.2020.0327
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