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Multi-model forecasts of the ongoing Ebola epidemic in the Democratic Republic of Congo, March–October 2019

The 2018–2020 Ebola outbreak in the Democratic Republic of the Congo is the first to occur in an armed conflict zone. The resulting impact on population movement, treatment centres and surveillance has created an unprecedented challenge for real-time epidemic forecasting. Most standard mathematical...

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Autores principales: Roosa, Kimberlyn, Tariq, Amna, Yan, Ping, Hyman, James M., Chowell, Gerardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7482568/
https://www.ncbi.nlm.nih.gov/pubmed/32842888
http://dx.doi.org/10.1098/rsif.2020.0447
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author Roosa, Kimberlyn
Tariq, Amna
Yan, Ping
Hyman, James M.
Chowell, Gerardo
author_facet Roosa, Kimberlyn
Tariq, Amna
Yan, Ping
Hyman, James M.
Chowell, Gerardo
author_sort Roosa, Kimberlyn
collection PubMed
description The 2018–2020 Ebola outbreak in the Democratic Republic of the Congo is the first to occur in an armed conflict zone. The resulting impact on population movement, treatment centres and surveillance has created an unprecedented challenge for real-time epidemic forecasting. Most standard mathematical models cannot capture the observed incidence trajectory when it deviates from a traditional epidemic logistic curve. We fit seven dynamic models of increasing complexity to the incidence data published in the World Health Organization Situation Reports, after adjusting for reporting delays. These models include a simple logistic model, a Richards model, an endemic Richards model, a double logistic growth model, a multi-model approach and two sub-epidemic models. We analyse model fit to the data and compare real-time forecasts throughout the ongoing epidemic across 29 weeks from 11 March to 23 September 2019. We observe that the modest extensions presented allow for capturing a wide range of epidemic behaviour. The multi-model approach yields the most reliable forecasts on average for this application, and the presented extensions improve model flexibility and forecasting accuracy, even in the context of limited epidemiological data.
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spelling pubmed-74825682020-09-18 Multi-model forecasts of the ongoing Ebola epidemic in the Democratic Republic of Congo, March–October 2019 Roosa, Kimberlyn Tariq, Amna Yan, Ping Hyman, James M. Chowell, Gerardo J R Soc Interface Life Sciences–Mathematics interface The 2018–2020 Ebola outbreak in the Democratic Republic of the Congo is the first to occur in an armed conflict zone. The resulting impact on population movement, treatment centres and surveillance has created an unprecedented challenge for real-time epidemic forecasting. Most standard mathematical models cannot capture the observed incidence trajectory when it deviates from a traditional epidemic logistic curve. We fit seven dynamic models of increasing complexity to the incidence data published in the World Health Organization Situation Reports, after adjusting for reporting delays. These models include a simple logistic model, a Richards model, an endemic Richards model, a double logistic growth model, a multi-model approach and two sub-epidemic models. We analyse model fit to the data and compare real-time forecasts throughout the ongoing epidemic across 29 weeks from 11 March to 23 September 2019. We observe that the modest extensions presented allow for capturing a wide range of epidemic behaviour. The multi-model approach yields the most reliable forecasts on average for this application, and the presented extensions improve model flexibility and forecasting accuracy, even in the context of limited epidemiological data. The Royal Society 2020-08 2020-08-26 /pmc/articles/PMC7482568/ /pubmed/32842888 http://dx.doi.org/10.1098/rsif.2020.0447 Text en © 2020 The Authors. http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/http://creativecommons.org/licenses/by/4.0/Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
spellingShingle Life Sciences–Mathematics interface
Roosa, Kimberlyn
Tariq, Amna
Yan, Ping
Hyman, James M.
Chowell, Gerardo
Multi-model forecasts of the ongoing Ebola epidemic in the Democratic Republic of Congo, March–October 2019
title Multi-model forecasts of the ongoing Ebola epidemic in the Democratic Republic of Congo, March–October 2019
title_full Multi-model forecasts of the ongoing Ebola epidemic in the Democratic Republic of Congo, March–October 2019
title_fullStr Multi-model forecasts of the ongoing Ebola epidemic in the Democratic Republic of Congo, March–October 2019
title_full_unstemmed Multi-model forecasts of the ongoing Ebola epidemic in the Democratic Republic of Congo, March–October 2019
title_short Multi-model forecasts of the ongoing Ebola epidemic in the Democratic Republic of Congo, March–October 2019
title_sort multi-model forecasts of the ongoing ebola epidemic in the democratic republic of congo, march–october 2019
topic Life Sciences–Mathematics interface
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7482568/
https://www.ncbi.nlm.nih.gov/pubmed/32842888
http://dx.doi.org/10.1098/rsif.2020.0447
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