On the genetics and immunopathogenesis of COVID-19

Most severe cases with COVID-19, especially those with pulmonary failure, are not a consequence of viral burden and/or failure of the ‘adaptive’ immune response to subdue the pathogen by utilizing an adequate ‘adaptive’ immune defense. Rather it is a consequence of immunopathology, resulting from im...

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Detalles Bibliográficos
Autor principal: Jacob, Chaim Oscar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7482598/
https://www.ncbi.nlm.nih.gov/pubmed/32920210
http://dx.doi.org/10.1016/j.clim.2020.108591
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author Jacob, Chaim Oscar
author_facet Jacob, Chaim Oscar
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description Most severe cases with COVID-19, especially those with pulmonary failure, are not a consequence of viral burden and/or failure of the ‘adaptive’ immune response to subdue the pathogen by utilizing an adequate ‘adaptive’ immune defense. Rather it is a consequence of immunopathology, resulting from imbalanced innate immune response, which may not be linked to pathogen burden at all. In fact, it might be described as an autoinflammatory disease. The Kawasaki-like disease seen in children with SARS-CoV-2 exposure might be another example of similar mechanism.
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spelling pubmed-74825982020-09-11 On the genetics and immunopathogenesis of COVID-19 Jacob, Chaim Oscar Clin Immunol Review Article Most severe cases with COVID-19, especially those with pulmonary failure, are not a consequence of viral burden and/or failure of the ‘adaptive’ immune response to subdue the pathogen by utilizing an adequate ‘adaptive’ immune defense. Rather it is a consequence of immunopathology, resulting from imbalanced innate immune response, which may not be linked to pathogen burden at all. In fact, it might be described as an autoinflammatory disease. The Kawasaki-like disease seen in children with SARS-CoV-2 exposure might be another example of similar mechanism. Elsevier Inc. 2020-11 2020-09-10 /pmc/articles/PMC7482598/ /pubmed/32920210 http://dx.doi.org/10.1016/j.clim.2020.108591 Text en © 2020 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review Article
Jacob, Chaim Oscar
On the genetics and immunopathogenesis of COVID-19
title On the genetics and immunopathogenesis of COVID-19
title_full On the genetics and immunopathogenesis of COVID-19
title_fullStr On the genetics and immunopathogenesis of COVID-19
title_full_unstemmed On the genetics and immunopathogenesis of COVID-19
title_short On the genetics and immunopathogenesis of COVID-19
title_sort on the genetics and immunopathogenesis of covid-19
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7482598/
https://www.ncbi.nlm.nih.gov/pubmed/32920210
http://dx.doi.org/10.1016/j.clim.2020.108591
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