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Mortality burden from seasonal influenza in Chongqing, China, 2012–2018

PURPOSE: To estimate influenza-associated excess mortality rates (EMRs) in Chongqing from 2012 to 2018. METHODS: We obtained weekly mortality data for all-cause and four underlying causes of death (circulatory and respiratory disease (CRD), pneumonia and influenza (P&I), chronic obstructive pulm...

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Autores principales: Qi, Li, Li, Qin, Ding, Xian-Bin, Gao, Yuan, Ling, Hua, Liu, Tian, Xiong, Yu, Su, Kun, Tang, Wen-Ge, Feng, Lu-Zhao, Liu, Qi-Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7482776/
https://www.ncbi.nlm.nih.gov/pubmed/32343618
http://dx.doi.org/10.1080/21645515.2019.1693721
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author Qi, Li
Li, Qin
Ding, Xian-Bin
Gao, Yuan
Ling, Hua
Liu, Tian
Xiong, Yu
Su, Kun
Tang, Wen-Ge
Feng, Lu-Zhao
Liu, Qi-Yong
author_facet Qi, Li
Li, Qin
Ding, Xian-Bin
Gao, Yuan
Ling, Hua
Liu, Tian
Xiong, Yu
Su, Kun
Tang, Wen-Ge
Feng, Lu-Zhao
Liu, Qi-Yong
author_sort Qi, Li
collection PubMed
description PURPOSE: To estimate influenza-associated excess mortality rates (EMRs) in Chongqing from 2012 to 2018. METHODS: We obtained weekly mortality data for all-cause and four underlying causes of death (circulatory and respiratory disease (CRD), pneumonia and influenza (P&I), chronic obstructive pulmonary disease (COPD) and ischemic heart disease (IDH)), and influenza surveillance data, from 2012 to 2018. A negative-binomial regression model was used to estimate influenza-associated EMRs in two age groups (<65 years and ≥65 years). RESULTS: It was estimated that an annual average of 10025 influenza-associated deaths occurred in Chongqing, corresponding to 5.2% of all deaths. The average EMR for all-cause death associated with influenza was 33.5 (95% confidence interval (CI): 31.5–35.6) per 100 000 persons, and in separate cause-specific models we attributed 24.7 (95% CI: 23.3–26.0), 0.8 (95% CI: 0.7–0.8), 8.5 (95% CI: 8.1–9.0) and 5.0 (95% CI: 4.7–5.3) per 100 000 persons EMRs to CRD, P&I, COPD and IDH, respectively. The estimated EMR for influenza B virus was 20.6 (95% CI: 20.3–21.0), which was significantly higher than the rates of 5.3 (95% CI: 4.5–6.1) and 7.5 (95% CI: 6.7–8.3) for A(H3N2) and A(H1N1) pdm09 virus, respectively. The estimated EMR was 152.3 (95% CI: 136.1–168.4) for people aged ≥65 years, which was significantly higher than the rate for those aged <65 years (6.8, 95% CI: 6.3–7.2). CONCLUSIONS: Influenza was associated with substantial EMRs in Chongqing, especially among elderly people. Influenza B virus caused a relatively higher excess mortality impact compared with A(H1N1)pdm09 and A(H3N2). It is advisable to optimize future seasonal influenza vaccine reimbursement policy in Chongqing to curb disease burden.
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spelling pubmed-74827762020-09-16 Mortality burden from seasonal influenza in Chongqing, China, 2012–2018 Qi, Li Li, Qin Ding, Xian-Bin Gao, Yuan Ling, Hua Liu, Tian Xiong, Yu Su, Kun Tang, Wen-Ge Feng, Lu-Zhao Liu, Qi-Yong Hum Vaccin Immunother Research Paper PURPOSE: To estimate influenza-associated excess mortality rates (EMRs) in Chongqing from 2012 to 2018. METHODS: We obtained weekly mortality data for all-cause and four underlying causes of death (circulatory and respiratory disease (CRD), pneumonia and influenza (P&I), chronic obstructive pulmonary disease (COPD) and ischemic heart disease (IDH)), and influenza surveillance data, from 2012 to 2018. A negative-binomial regression model was used to estimate influenza-associated EMRs in two age groups (<65 years and ≥65 years). RESULTS: It was estimated that an annual average of 10025 influenza-associated deaths occurred in Chongqing, corresponding to 5.2% of all deaths. The average EMR for all-cause death associated with influenza was 33.5 (95% confidence interval (CI): 31.5–35.6) per 100 000 persons, and in separate cause-specific models we attributed 24.7 (95% CI: 23.3–26.0), 0.8 (95% CI: 0.7–0.8), 8.5 (95% CI: 8.1–9.0) and 5.0 (95% CI: 4.7–5.3) per 100 000 persons EMRs to CRD, P&I, COPD and IDH, respectively. The estimated EMR for influenza B virus was 20.6 (95% CI: 20.3–21.0), which was significantly higher than the rates of 5.3 (95% CI: 4.5–6.1) and 7.5 (95% CI: 6.7–8.3) for A(H3N2) and A(H1N1) pdm09 virus, respectively. The estimated EMR was 152.3 (95% CI: 136.1–168.4) for people aged ≥65 years, which was significantly higher than the rate for those aged <65 years (6.8, 95% CI: 6.3–7.2). CONCLUSIONS: Influenza was associated with substantial EMRs in Chongqing, especially among elderly people. Influenza B virus caused a relatively higher excess mortality impact compared with A(H1N1)pdm09 and A(H3N2). It is advisable to optimize future seasonal influenza vaccine reimbursement policy in Chongqing to curb disease burden. Taylor & Francis 2020-04-28 /pmc/articles/PMC7482776/ /pubmed/32343618 http://dx.doi.org/10.1080/21645515.2019.1693721 Text en © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Paper
Qi, Li
Li, Qin
Ding, Xian-Bin
Gao, Yuan
Ling, Hua
Liu, Tian
Xiong, Yu
Su, Kun
Tang, Wen-Ge
Feng, Lu-Zhao
Liu, Qi-Yong
Mortality burden from seasonal influenza in Chongqing, China, 2012–2018
title Mortality burden from seasonal influenza in Chongqing, China, 2012–2018
title_full Mortality burden from seasonal influenza in Chongqing, China, 2012–2018
title_fullStr Mortality burden from seasonal influenza in Chongqing, China, 2012–2018
title_full_unstemmed Mortality burden from seasonal influenza in Chongqing, China, 2012–2018
title_short Mortality burden from seasonal influenza in Chongqing, China, 2012–2018
title_sort mortality burden from seasonal influenza in chongqing, china, 2012–2018
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7482776/
https://www.ncbi.nlm.nih.gov/pubmed/32343618
http://dx.doi.org/10.1080/21645515.2019.1693721
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