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A role for gorilla APOBEC3G in shaping lentivirus evolution including transmission to humans
The APOBEC3 deaminases are potent inhibitors of virus replication and barriers to cross-species transmission. For simian immunodeficiency virus (SIV) to transmit to a new primate host, as happened multiple times to seed the ongoing HIV-1 epidemic, the viral infectivity factor (Vif) must be capable o...
Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7482973/ https://www.ncbi.nlm.nih.gov/pubmed/32913367 http://dx.doi.org/10.1371/journal.ppat.1008812 |
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author | Nakano, Yusuke Yamamoto, Keisuke Ueda, Mahoko Takahashi Soper, Andrew Konno, Yoriyuki Kimura, Izumi Uriu, Keiya Kumata, Ryuichi Aso, Hirofumi Misawa, Naoko Nagaoka, Shumpei Shimizu, Soma Mitsumune, Keito Kosugi, Yusuke Juarez-Fernandez, Guillermo Ito, Jumpei Nakagawa, So Ikeda, Terumasa Koyanagi, Yoshio Harris, Reuben S. Sato, Kei |
author_facet | Nakano, Yusuke Yamamoto, Keisuke Ueda, Mahoko Takahashi Soper, Andrew Konno, Yoriyuki Kimura, Izumi Uriu, Keiya Kumata, Ryuichi Aso, Hirofumi Misawa, Naoko Nagaoka, Shumpei Shimizu, Soma Mitsumune, Keito Kosugi, Yusuke Juarez-Fernandez, Guillermo Ito, Jumpei Nakagawa, So Ikeda, Terumasa Koyanagi, Yoshio Harris, Reuben S. Sato, Kei |
author_sort | Nakano, Yusuke |
collection | PubMed |
description | The APOBEC3 deaminases are potent inhibitors of virus replication and barriers to cross-species transmission. For simian immunodeficiency virus (SIV) to transmit to a new primate host, as happened multiple times to seed the ongoing HIV-1 epidemic, the viral infectivity factor (Vif) must be capable of neutralizing the APOBEC3 enzymes of the new host. Although much is known about current interactions of HIV-1 Vif and human APOBEC3s, the evolutionary changes in SIV Vif required for transmission from chimpanzees to gorillas and ultimately to humans are poorly understood. Here, we demonstrate that gorilla APOBEC3G is a factor with the potential to hamper SIV transmission from chimpanzees to gorillas. Gain-of-function experiments using SIVcpzPtt Vif revealed that this barrier could be overcome by a single Vif acidic amino acid substitution (M16E). Moreover, degradation of gorilla APOBEC3F is induced by Vif through a mechanism that is distinct from that of human APOBEC3F. Thus, our findings identify virus adaptations in gorillas that preceded and may have facilitated transmission to humans. |
format | Online Article Text |
id | pubmed-7482973 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-74829732020-09-21 A role for gorilla APOBEC3G in shaping lentivirus evolution including transmission to humans Nakano, Yusuke Yamamoto, Keisuke Ueda, Mahoko Takahashi Soper, Andrew Konno, Yoriyuki Kimura, Izumi Uriu, Keiya Kumata, Ryuichi Aso, Hirofumi Misawa, Naoko Nagaoka, Shumpei Shimizu, Soma Mitsumune, Keito Kosugi, Yusuke Juarez-Fernandez, Guillermo Ito, Jumpei Nakagawa, So Ikeda, Terumasa Koyanagi, Yoshio Harris, Reuben S. Sato, Kei PLoS Pathog Research Article The APOBEC3 deaminases are potent inhibitors of virus replication and barriers to cross-species transmission. For simian immunodeficiency virus (SIV) to transmit to a new primate host, as happened multiple times to seed the ongoing HIV-1 epidemic, the viral infectivity factor (Vif) must be capable of neutralizing the APOBEC3 enzymes of the new host. Although much is known about current interactions of HIV-1 Vif and human APOBEC3s, the evolutionary changes in SIV Vif required for transmission from chimpanzees to gorillas and ultimately to humans are poorly understood. Here, we demonstrate that gorilla APOBEC3G is a factor with the potential to hamper SIV transmission from chimpanzees to gorillas. Gain-of-function experiments using SIVcpzPtt Vif revealed that this barrier could be overcome by a single Vif acidic amino acid substitution (M16E). Moreover, degradation of gorilla APOBEC3F is induced by Vif through a mechanism that is distinct from that of human APOBEC3F. Thus, our findings identify virus adaptations in gorillas that preceded and may have facilitated transmission to humans. Public Library of Science 2020-09-10 /pmc/articles/PMC7482973/ /pubmed/32913367 http://dx.doi.org/10.1371/journal.ppat.1008812 Text en © 2020 Nakano et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Nakano, Yusuke Yamamoto, Keisuke Ueda, Mahoko Takahashi Soper, Andrew Konno, Yoriyuki Kimura, Izumi Uriu, Keiya Kumata, Ryuichi Aso, Hirofumi Misawa, Naoko Nagaoka, Shumpei Shimizu, Soma Mitsumune, Keito Kosugi, Yusuke Juarez-Fernandez, Guillermo Ito, Jumpei Nakagawa, So Ikeda, Terumasa Koyanagi, Yoshio Harris, Reuben S. Sato, Kei A role for gorilla APOBEC3G in shaping lentivirus evolution including transmission to humans |
title | A role for gorilla APOBEC3G in shaping lentivirus evolution including transmission to humans |
title_full | A role for gorilla APOBEC3G in shaping lentivirus evolution including transmission to humans |
title_fullStr | A role for gorilla APOBEC3G in shaping lentivirus evolution including transmission to humans |
title_full_unstemmed | A role for gorilla APOBEC3G in shaping lentivirus evolution including transmission to humans |
title_short | A role for gorilla APOBEC3G in shaping lentivirus evolution including transmission to humans |
title_sort | role for gorilla apobec3g in shaping lentivirus evolution including transmission to humans |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7482973/ https://www.ncbi.nlm.nih.gov/pubmed/32913367 http://dx.doi.org/10.1371/journal.ppat.1008812 |
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