Antibody-dependent enhancement of coronavirus

Antibody-dependent enhancement (ADE) exists in several kinds of virus. It has a negative influence on antibody therapy for viral infection. This effect was first identified in dengue virus and has since also been described for coronavirus. To date, the rapid spread of the newly emerged coronavirus,...

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Autores principales: Wen, Jieqi, Cheng, Yifan, Ling, Rongsong, Dai, Yarong, Huang, Boxuan, Huang, Wenjie, Zhang, Siyan, Jiang, Yizhou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7483033/
https://www.ncbi.nlm.nih.gov/pubmed/32920233
http://dx.doi.org/10.1016/j.ijid.2020.09.015
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author Wen, Jieqi
Cheng, Yifan
Ling, Rongsong
Dai, Yarong
Huang, Boxuan
Huang, Wenjie
Zhang, Siyan
Jiang, Yizhou
author_facet Wen, Jieqi
Cheng, Yifan
Ling, Rongsong
Dai, Yarong
Huang, Boxuan
Huang, Wenjie
Zhang, Siyan
Jiang, Yizhou
author_sort Wen, Jieqi
collection PubMed
description Antibody-dependent enhancement (ADE) exists in several kinds of virus. It has a negative influence on antibody therapy for viral infection. This effect was first identified in dengue virus and has since also been described for coronavirus. To date, the rapid spread of the newly emerged coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causing coronavirus disease 2019 (COVID-19), has affected over 3.8 million people across the globe. The novel coronavirus poses a great challenge and has caused a wave of panic. In this review, antibody-dependent enhancements in dengue virus and two kinds of coronavirus are summarized. Possible solutions for the effects are reported. We also speculate that ADE may exist in SARS-CoV-2.
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spelling pubmed-74830332020-09-11 Antibody-dependent enhancement of coronavirus Wen, Jieqi Cheng, Yifan Ling, Rongsong Dai, Yarong Huang, Boxuan Huang, Wenjie Zhang, Siyan Jiang, Yizhou Int J Infect Dis Review Antibody-dependent enhancement (ADE) exists in several kinds of virus. It has a negative influence on antibody therapy for viral infection. This effect was first identified in dengue virus and has since also been described for coronavirus. To date, the rapid spread of the newly emerged coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causing coronavirus disease 2019 (COVID-19), has affected over 3.8 million people across the globe. The novel coronavirus poses a great challenge and has caused a wave of panic. In this review, antibody-dependent enhancements in dengue virus and two kinds of coronavirus are summarized. Possible solutions for the effects are reported. We also speculate that ADE may exist in SARS-CoV-2. The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2020-11 2020-09-11 /pmc/articles/PMC7483033/ /pubmed/32920233 http://dx.doi.org/10.1016/j.ijid.2020.09.015 Text en © 2020 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review
Wen, Jieqi
Cheng, Yifan
Ling, Rongsong
Dai, Yarong
Huang, Boxuan
Huang, Wenjie
Zhang, Siyan
Jiang, Yizhou
Antibody-dependent enhancement of coronavirus
title Antibody-dependent enhancement of coronavirus
title_full Antibody-dependent enhancement of coronavirus
title_fullStr Antibody-dependent enhancement of coronavirus
title_full_unstemmed Antibody-dependent enhancement of coronavirus
title_short Antibody-dependent enhancement of coronavirus
title_sort antibody-dependent enhancement of coronavirus
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7483033/
https://www.ncbi.nlm.nih.gov/pubmed/32920233
http://dx.doi.org/10.1016/j.ijid.2020.09.015
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