Inhibition of LSD1 in MDS Progenitors Restores Differentiation of CD141(Hi) Conventional Dendritic Cells

The use of immunotherapy to treat patients with myelodysplastic syndromes (MDS) shows promise but is limited by our incomplete understanding of the immunologic milieu. In solid tumors, CD141(Hi) conventional dendritic cells (CD141(Hi) cDCs) are necessary for anti-tumor immunosurveillance and the res...

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Detalles Bibliográficos
Autores principales: Srivastava, Pragya, Tzetzo, Stephanie L., Gomez, Eduardo Cortes, Eng, Kevin H., Sait, Sheila N. Jani, Kuechle, Joseph B., Singh, Prashant K., De Jong, Kitty, Wiatrowski, Kyle R., Peresie, Jennifer, Dimitroff, Ava, Lynch, Miranda L., Wang, Jianmin, Abrams, Scott I., Griffiths, Elizabeth A., Nemeth, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7483249/
https://www.ncbi.nlm.nih.gov/pubmed/32099035
http://dx.doi.org/10.1038/s41375-020-0765-5

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