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A small molecular compound CC1007 induces cross-lineage differentiation by inhibiting HDAC7 expression and HDAC7/MEF2C interaction in BCR-ABL1(−) pre-B-ALL
Histone deacetylase 7 (HDAC7), a member of class IIa HDACs, has been described to be an important regulator for B cell development and has a potential role in B cell acute lymphoblastic leukemia (B-ALL). CC1007, a BML-210 analog, is designed to indirectly inhibit class IIa HDACs by binding to myocyt...
Autores principales: | Wang, Zhihua, Zhang, Yang, Zhu, Shicong, Peng, Hongling, Chen, Yongheng, Cheng, Zhao, Liu, Sufang, Luo, Yunya, Li, Ruijuan, Deng, Mingyang, Xu, Yunxiao, Hu, Guoyu, Chen, Lin, Zhang, Guangsen |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7483467/ https://www.ncbi.nlm.nih.gov/pubmed/32913188 http://dx.doi.org/10.1038/s41419-020-02949-1 |
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