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Low-Frequency Intrapulmonary Percussive Ventilation Increases Aerosol Penetration in a 2-Compartment Physical Model of Fibrotic Lung Disease
In patients with fibrotic pulmonary disease such as idiopathic pulmonary fibrosis (IPF), inhaled aerosols deposit mostly in the less affected region of the lungs, resulting in suboptimal pharmacokinetics of airway-delivered treatments. Refinement of aerosol delivery technique requires new models to...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7483496/ https://www.ncbi.nlm.nih.gov/pubmed/32984287 http://dx.doi.org/10.3389/fbioe.2020.01022 |
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author | Le Guellec, Sandrine Allimonnier, Laurine Heuzé-Vourc’h, Nathalie Cabrera, Maria Ossant, Frédéric Pourchez, Jérémie Vecellio, Laurent Plantier, Laurent |
author_facet | Le Guellec, Sandrine Allimonnier, Laurine Heuzé-Vourc’h, Nathalie Cabrera, Maria Ossant, Frédéric Pourchez, Jérémie Vecellio, Laurent Plantier, Laurent |
author_sort | Le Guellec, Sandrine |
collection | PubMed |
description | In patients with fibrotic pulmonary disease such as idiopathic pulmonary fibrosis (IPF), inhaled aerosols deposit mostly in the less affected region of the lungs, resulting in suboptimal pharmacokinetics of airway-delivered treatments. Refinement of aerosol delivery technique requires new models to simulate the major alterations of lung physiology associated with IPF, i.e., heterogeneously reduced lung compliance and increased airway caliber. A novel physical model of the respiratory system was constructed to simulate aerosol drug delivery in spontaneously breathing (negative pressure ventilation) IPF patients. The model comprises upper (Alberta ideal throat) and lower airway (plastic tubing) models and branches into two compartments (Michigan lung models) which differ in compliance and caliber of conducting airway. The model was able to reproduce the heterogeneous, compliance-dependent reduction in ventilation and aerosol penetration (using NaF as a model aerosol) seen in fibrotic lung regions in IPF. Of note, intrapulmonary percussive ventilation induced a 2–3-fold increase in aerosol penetration in the low-compliance/high airway caliber compartment of the model, demonstrating the responsiveness of the model to therapeutic intervention. |
format | Online Article Text |
id | pubmed-7483496 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-74834962020-09-26 Low-Frequency Intrapulmonary Percussive Ventilation Increases Aerosol Penetration in a 2-Compartment Physical Model of Fibrotic Lung Disease Le Guellec, Sandrine Allimonnier, Laurine Heuzé-Vourc’h, Nathalie Cabrera, Maria Ossant, Frédéric Pourchez, Jérémie Vecellio, Laurent Plantier, Laurent Front Bioeng Biotechnol Bioengineering and Biotechnology In patients with fibrotic pulmonary disease such as idiopathic pulmonary fibrosis (IPF), inhaled aerosols deposit mostly in the less affected region of the lungs, resulting in suboptimal pharmacokinetics of airway-delivered treatments. Refinement of aerosol delivery technique requires new models to simulate the major alterations of lung physiology associated with IPF, i.e., heterogeneously reduced lung compliance and increased airway caliber. A novel physical model of the respiratory system was constructed to simulate aerosol drug delivery in spontaneously breathing (negative pressure ventilation) IPF patients. The model comprises upper (Alberta ideal throat) and lower airway (plastic tubing) models and branches into two compartments (Michigan lung models) which differ in compliance and caliber of conducting airway. The model was able to reproduce the heterogeneous, compliance-dependent reduction in ventilation and aerosol penetration (using NaF as a model aerosol) seen in fibrotic lung regions in IPF. Of note, intrapulmonary percussive ventilation induced a 2–3-fold increase in aerosol penetration in the low-compliance/high airway caliber compartment of the model, demonstrating the responsiveness of the model to therapeutic intervention. Frontiers Media S.A. 2020-08-28 /pmc/articles/PMC7483496/ /pubmed/32984287 http://dx.doi.org/10.3389/fbioe.2020.01022 Text en Copyright © 2020 Le Guellec, Allimonnier, Heuzé-Vourc’h, Cabrera, Ossant, Pourchez, Vecellio and Plantier. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Bioengineering and Biotechnology Le Guellec, Sandrine Allimonnier, Laurine Heuzé-Vourc’h, Nathalie Cabrera, Maria Ossant, Frédéric Pourchez, Jérémie Vecellio, Laurent Plantier, Laurent Low-Frequency Intrapulmonary Percussive Ventilation Increases Aerosol Penetration in a 2-Compartment Physical Model of Fibrotic Lung Disease |
title | Low-Frequency Intrapulmonary Percussive Ventilation Increases Aerosol Penetration in a 2-Compartment Physical Model of Fibrotic Lung Disease |
title_full | Low-Frequency Intrapulmonary Percussive Ventilation Increases Aerosol Penetration in a 2-Compartment Physical Model of Fibrotic Lung Disease |
title_fullStr | Low-Frequency Intrapulmonary Percussive Ventilation Increases Aerosol Penetration in a 2-Compartment Physical Model of Fibrotic Lung Disease |
title_full_unstemmed | Low-Frequency Intrapulmonary Percussive Ventilation Increases Aerosol Penetration in a 2-Compartment Physical Model of Fibrotic Lung Disease |
title_short | Low-Frequency Intrapulmonary Percussive Ventilation Increases Aerosol Penetration in a 2-Compartment Physical Model of Fibrotic Lung Disease |
title_sort | low-frequency intrapulmonary percussive ventilation increases aerosol penetration in a 2-compartment physical model of fibrotic lung disease |
topic | Bioengineering and Biotechnology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7483496/ https://www.ncbi.nlm.nih.gov/pubmed/32984287 http://dx.doi.org/10.3389/fbioe.2020.01022 |
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