Integrated Metabolic Modeling, Culturing, and Transcriptomics Explain Enhanced Virulence of Vibrio cholerae during Coinfection with Enterotoxigenic Escherichia coli

Gene essentiality is altered during polymicrobial infections. Nevertheless, most studies rely on single-species infections to assess pathogen gene essentiality. Here, we use genome-scale metabolic models (GEMs) to explore the effect of coinfection of the diarrheagenic pathogen Vibrio cholerae with a...

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Detalles Bibliográficos
Autores principales: Abdel-Haleem, Alyaa M., Ravikumar, Vaishnavi, Ji, Boyang, Mineta, Katsuhiko, Gao, Xin, Nielsen, Jens, Gojobori, Takashi, Mijakovic, Ivan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7483508/
https://www.ncbi.nlm.nih.gov/pubmed/32900868
http://dx.doi.org/10.1128/mSystems.00491-20

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