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Structural Basis of CD4 Downregulation by HIV-1 Nef

The HIV-1 Nef protein suppresses multiple immune surveillance mechanisms to promote viral pathogenesis and is an attractive target for the development of novel therapeutics. A key function of Nef is to remove the CD4 receptor from the cell surface by hijacking clathrin- and AP2-dependent endocytosis...

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Detalles Bibliográficos
Autores principales:	Kwon, Yonghwa, Kaake, Robyn M., Echeverria, Ignacia, Suarez, Marissa, Shamsabadi, Mohammad Karimian, Stoneham, Charlotte, Ramirez, Peter W., Kress, Jacob, Singh, Rajendra, Sali, Andrej, Krogan, Nevan, Guatelli, John, Jia, Xiaofei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7483821/ https://www.ncbi.nlm.nih.gov/pubmed/32719457 http://dx.doi.org/10.1038/s41594-020-0463-z

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