FOXO1 promotes HIV Latency by suppressing ER stress in T cells

Quiescence is a hallmark of CD4(+) T cells latently infected with HIV-1. While reversing this quiescence is an effective approach to reactivate latent HIV from T cells in culture, it can cause deleterious cytokine dysregulation in patients. As a key regulator of T-cell quiescence, FOXO1 promotes lat...

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Detalles Bibliográficos
Autores principales: Vallejo-Gracia, Albert, Chen, Irene P., Perrone, Rosalba, Besnard, Emilie, Boehm, Daniela, Battivelli, Emilie, Tezil, Tugsan, Krey, Karsten, Raymond, Kyle A., Hull, Philip A., Walter, Marius, Habrylo, Ireneusz, Cruz, Andrew, Deeks, Steven, Pillai, Satish, Verdin, Eric, Ott, Melanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7483895/
https://www.ncbi.nlm.nih.gov/pubmed/32541947
http://dx.doi.org/10.1038/s41564-020-0742-9

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