DNA-Sensing Antiviral Innate Immunity in Poxvirus Infection

As pattern recognition receptors, cytosolic DNA sensors quickly induce an effective innate immune response. Poxvirus, a large DNA virus, is capable of evading the host antiviral innate immune response. In this review, we summarize the latest studies on how poxvirus is sensed by the host innate immun...

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Detalles Bibliográficos
Autores principales: Lu, Yue, Zhang, Leiliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7483915/
https://www.ncbi.nlm.nih.gov/pubmed/32983084
http://dx.doi.org/10.3389/fimmu.2020.01637
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author Lu, Yue
Zhang, Leiliang
author_facet Lu, Yue
Zhang, Leiliang
author_sort Lu, Yue
collection PubMed
description As pattern recognition receptors, cytosolic DNA sensors quickly induce an effective innate immune response. Poxvirus, a large DNA virus, is capable of evading the host antiviral innate immune response. In this review, we summarize the latest studies on how poxvirus is sensed by the host innate immune system and how poxvirus-encoded proteins antagonize DNA sensors. A comprehensive understanding of the interplay between poxvirus and DNA-sensing antiviral immune responses of the host will contribute to the development of new antiviral therapies and vaccines in the future.
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spelling pubmed-74839152020-09-25 DNA-Sensing Antiviral Innate Immunity in Poxvirus Infection Lu, Yue Zhang, Leiliang Front Immunol Immunology As pattern recognition receptors, cytosolic DNA sensors quickly induce an effective innate immune response. Poxvirus, a large DNA virus, is capable of evading the host antiviral innate immune response. In this review, we summarize the latest studies on how poxvirus is sensed by the host innate immune system and how poxvirus-encoded proteins antagonize DNA sensors. A comprehensive understanding of the interplay between poxvirus and DNA-sensing antiviral immune responses of the host will contribute to the development of new antiviral therapies and vaccines in the future. Frontiers Media S.A. 2020-08-28 /pmc/articles/PMC7483915/ /pubmed/32983084 http://dx.doi.org/10.3389/fimmu.2020.01637 Text en Copyright © 2020 Lu and Zhang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Lu, Yue
Zhang, Leiliang
DNA-Sensing Antiviral Innate Immunity in Poxvirus Infection
title DNA-Sensing Antiviral Innate Immunity in Poxvirus Infection
title_full DNA-Sensing Antiviral Innate Immunity in Poxvirus Infection
title_fullStr DNA-Sensing Antiviral Innate Immunity in Poxvirus Infection
title_full_unstemmed DNA-Sensing Antiviral Innate Immunity in Poxvirus Infection
title_short DNA-Sensing Antiviral Innate Immunity in Poxvirus Infection
title_sort dna-sensing antiviral innate immunity in poxvirus infection
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7483915/
https://www.ncbi.nlm.nih.gov/pubmed/32983084
http://dx.doi.org/10.3389/fimmu.2020.01637
work_keys_str_mv AT luyue dnasensingantiviralinnateimmunityinpoxvirusinfection
AT zhangleiliang dnasensingantiviralinnateimmunityinpoxvirusinfection

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