Extrachromosomal DNA is associated with oncogene amplification and poor outcome across multiple cancers

Extrachromosomal DNA (ecDNA) amplification promotes intratumoral genetic heterogeneity and accelerated tumor evolution(1–3), but its frequency and clinical impact are unclear. Here we show, using computational analysis of whole-genome sequencing data from 3,212 cancer patients, that ecDNA amplificat...

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Detalles Bibliográficos
Autores principales: Kim, Hoon, Nguyen, Nam-Phuong, Turner, Kristen, Wu, Sihan, Gujar, Amit D., Luebeck, Jens, Liu, Jihe, Deshpande, Viraj, Rajkumar, Utkrisht, Namburi, Sandeep, Amin, Samirkumar B., Yi, Eunhee, Menghi, Francesca, Schulte, Johannes H., Henssen, Anton G., Chang, Howard Y., Beck, Christine, Mischel, Paul S., Bafna, Vineet, Verhaak, Roel G.W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7484012/
https://www.ncbi.nlm.nih.gov/pubmed/32807987
http://dx.doi.org/10.1038/s41588-020-0678-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7484012/
https://www.ncbi.nlm.nih.gov/pubmed/32807987
http://dx.doi.org/10.1038/s41588-020-0678-2

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