Uncoupling sodium channel dimers restores the phenotype of a pain‐linked Na(v)1.7 channel mutation

BACKGROUND AND PURPOSE: The voltage‐gated sodium channel Na(v)1.7 is essential for adequate perception of painful stimuli. Mutations in the encoding gene, SCN9A, cause various pain syndromes in humans. The hNa(v)1.7/A1632E channel mutant causes symptoms of erythromelalgia and paroxysmal extreme pain...

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Detalles Bibliográficos
Autores principales: Rühlmann, Annika H., Körner, Jannis, Hausmann, Ralf, Bebrivenski, Nikolay, Neuhof, Christian, Detro‐Dassen, Silvia, Hautvast, Petra, Benasolo, Carène A., Meents, Jannis, Machtens, Jan‐Philipp, Schmalzing, Günther, Lampert, Angelika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7484505/
https://www.ncbi.nlm.nih.gov/pubmed/32663327
http://dx.doi.org/10.1111/bph.15196

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