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Inhibition of Bruton's TK regulates macrophage NF‐κB and NLRP3 inflammasome activation in metabolic inflammation

BACKGROUND AND PURPOSE: There are no medications currently available to treat metabolic inflammation. Bruton's tyrosine kinase (BTK) is highly expressed in monocytes and macrophages and regulates NF‐κB and NLRP3 inflammasome activity; both propagate metabolic inflammation in diet‐induced obesit...

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Detalles Bibliográficos
Autores principales:	Purvis, Gareth S.D., Collino, Massimo, Aranda‐Tavio, Haidee, Chiazza, Fausto, O'Riordan, Caroline E., Zeboudj, Lynda, Mohammad, Shireen, Collotta, Debora, Verta, Roberta, Guisot, Nicolas E.S., Bunyard, Peter, Yaqoob, Magdi M., Greaves, David R., Thiemermann, Christoph
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Research Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7484557/ https://www.ncbi.nlm.nih.gov/pubmed/32608058 http://dx.doi.org/10.1111/bph.15182

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