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Impact of N-Acyl-Homoserine Lactones, Quorum Sensing Molecules, on Gut Immunity
Among numerous molecules found in the gut ecosystem, quorum sensing (QS) molecules represent an overlooked part that warrants highlighting. QS relies on the release of small molecules (auto-inducers) by bacteria that accumulate in the environment depending on bacterial cell density. These molecules...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7484616/ https://www.ncbi.nlm.nih.gov/pubmed/32983093 http://dx.doi.org/10.3389/fimmu.2020.01827 |
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author | Coquant, Garance Grill, Jean-Pierre Seksik, Philippe |
author_facet | Coquant, Garance Grill, Jean-Pierre Seksik, Philippe |
author_sort | Coquant, Garance |
collection | PubMed |
description | Among numerous molecules found in the gut ecosystem, quorum sensing (QS) molecules represent an overlooked part that warrants highlighting. QS relies on the release of small molecules (auto-inducers) by bacteria that accumulate in the environment depending on bacterial cell density. These molecules not only are sensed by the microbial community but also interact with host cells and contribute to gut homeostasis. It therefore appears entirely appropriate to highlight the role of these molecules on the immune system in dysbiosis-associated inflammatory conditions where the bacterial populations are imbalanced. Here, we intent to focus on one of the most studied QS molecule family, namely, the type I auto-inducers represented by N-acyl-homoserine lactones (AHL). First described in pathogens such as Pseudomonas aeruginosa, these molecules have also been found in commensals and have been recently described within the complex microbial communities of the mammalian intestinal tract. In this mini-review, we will expound on this emergent field of research. We will first recall evidence on AHL structure, synthesis, receptors, and functions regarding interbacterial communication. Then, we will discuss their interactions with the host and particularly with agents of the innate and adaptive gut mucosa immunity. This will reveal how this new set of molecules, driven by microbial imbalance, can interact with inflammation pathways and could be a potential target in inflammatory bowel disease (IBD). The discovery of the general impact of these compounds on the detection of the bacterial quorum and on the dynamic and immune responses of eukaryotic cells opens up a new field of pathophysiology. |
format | Online Article Text |
id | pubmed-7484616 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-74846162020-09-24 Impact of N-Acyl-Homoserine Lactones, Quorum Sensing Molecules, on Gut Immunity Coquant, Garance Grill, Jean-Pierre Seksik, Philippe Front Immunol Immunology Among numerous molecules found in the gut ecosystem, quorum sensing (QS) molecules represent an overlooked part that warrants highlighting. QS relies on the release of small molecules (auto-inducers) by bacteria that accumulate in the environment depending on bacterial cell density. These molecules not only are sensed by the microbial community but also interact with host cells and contribute to gut homeostasis. It therefore appears entirely appropriate to highlight the role of these molecules on the immune system in dysbiosis-associated inflammatory conditions where the bacterial populations are imbalanced. Here, we intent to focus on one of the most studied QS molecule family, namely, the type I auto-inducers represented by N-acyl-homoserine lactones (AHL). First described in pathogens such as Pseudomonas aeruginosa, these molecules have also been found in commensals and have been recently described within the complex microbial communities of the mammalian intestinal tract. In this mini-review, we will expound on this emergent field of research. We will first recall evidence on AHL structure, synthesis, receptors, and functions regarding interbacterial communication. Then, we will discuss their interactions with the host and particularly with agents of the innate and adaptive gut mucosa immunity. This will reveal how this new set of molecules, driven by microbial imbalance, can interact with inflammation pathways and could be a potential target in inflammatory bowel disease (IBD). The discovery of the general impact of these compounds on the detection of the bacterial quorum and on the dynamic and immune responses of eukaryotic cells opens up a new field of pathophysiology. Frontiers Media S.A. 2020-08-28 /pmc/articles/PMC7484616/ /pubmed/32983093 http://dx.doi.org/10.3389/fimmu.2020.01827 Text en Copyright © 2020 Coquant, Grill and Seksik. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Coquant, Garance Grill, Jean-Pierre Seksik, Philippe Impact of N-Acyl-Homoserine Lactones, Quorum Sensing Molecules, on Gut Immunity |
title | Impact of N-Acyl-Homoserine Lactones, Quorum Sensing Molecules, on Gut Immunity |
title_full | Impact of N-Acyl-Homoserine Lactones, Quorum Sensing Molecules, on Gut Immunity |
title_fullStr | Impact of N-Acyl-Homoserine Lactones, Quorum Sensing Molecules, on Gut Immunity |
title_full_unstemmed | Impact of N-Acyl-Homoserine Lactones, Quorum Sensing Molecules, on Gut Immunity |
title_short | Impact of N-Acyl-Homoserine Lactones, Quorum Sensing Molecules, on Gut Immunity |
title_sort | impact of n-acyl-homoserine lactones, quorum sensing molecules, on gut immunity |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7484616/ https://www.ncbi.nlm.nih.gov/pubmed/32983093 http://dx.doi.org/10.3389/fimmu.2020.01827 |
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