Cargando…

COVID-19: Rational discovery of the therapeutic potential of Melatonin as a SARS-CoV-2 main Protease Inhibitor

The SARS-CoV-2 spread quickly across the globe. The World Health Organization (WHO) on March 11 declared COVID-19 a pandemic. The mortality rate, hospital disorders and incalculable economic and social damages, besides the unproven efficacy of the treatments evaluated against COVID-19, raised the ne...

Descripción completa

Detalles Bibliográficos
Autores principales:	Feitosa, Eduardo L, Júnior, Francisco Tiago Dos S S, Nery Neto, José Arimatéa De O, Matos, Luis F L, Moura, Matheus H De S, Rosales, Thiele Osvaldt, De Freitas, Guilherme Barroso L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2020
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7484667/ https://www.ncbi.nlm.nih.gov/pubmed/32922174 http://dx.doi.org/10.7150/ijms.48053

Ejemplares similares

Computational screening for potential drug candidates against the SARS-CoV-2 main protease
por: Silva Andrade, Bruno, et al.
Publicado: (2020)

Virtual screening based on molecular docking of possible inhibitors of Covid-19 main protease
por: Marinho, Emanuelle Machado, et al.
Publicado: (2020)

Rational design of potent anti-COVID-19 main protease drugs: An extensive multi-spectrum in silico approach
por: Ahmad, Sajjad, et al.
Publicado: (2021)

Computational approach towards the design of artemisinin–thymoquinone hybrids against main protease of SARS-COV-2
por: de Oliveira, Victor Moreira, et al.
Publicado: (2021)

Rational Discovery of Antiviral Whey Protein-Derived Small Peptides Targeting the SARS-CoV-2 Main Protease
por: Gambacorta, Nicola, et al.
Publicado: (2022)

Enteroendocrine cells and gut hormones as potential targets in the crossroad of the gut-kidney axis communication
por: Nery Neto, José Arimatéa de Oliveira, et al.
Publicado: (2023)

Valorization of polyphenolic compounds from food industry by-products for application in polysaccharide-based nanoparticles
por: Rosales, Thiécla Katiane Osvaldt, et al.
Publicado: (2023)

Crisis management and the dilemma of rationing strategies in healthcare organizations
por: Moura-Neto, José A., et al.
Publicado: (2018)

Identification of potential edible mushroom as SARS-CoV-2 main protease inhibitor using rational drug designing approach
por: Sen, Debanjan, et al.
Publicado: (2022)

Extrapolation and rational approximation: the works of the main contributors
por: Brezinski, Claude, et al.
Publicado: (2020)

Melatonin as a rational alternative in the conservative treatment of resistant hypertension
por: Simko, Fedor, et al.
Publicado: (2019)

Molecular docking identification for the efficacy of natural limonoids against COVID-19 virus main protease
por: de Oliveira, Victor Moreira, et al.
Publicado: (2021)

Rational approach toward COVID-19 main protease inhibitors via molecular docking, molecular dynamics simulation and free energy calculation
por: Keretsu, Seketoulie, et al.
Publicado: (2020)

Urinary Excretion of 6-Sulfatoxymelatonin, the Main Metabolite of Melatonin, and Mortality in Stable Outpatient Renal Transplant Recipients
por: van der Veen, Anna, et al.
Publicado: (2020)

Potential SARS-CoV-2 main protease inhibitors
por: Banerjee, Riddhidev, et al.
Publicado: (2021)

Enantioselective inhibition of the SARS-CoV-2 main protease with rhenium(i) picolinic acid complexes
por: Karges, Johannes, et al.
Publicado: (2022)

Multistep rational molecular design and combined docking for discovery of novel classes of inhibitors of SARS-CoV-2 main protease 3CLpro
por: Tumskiy, Roman S., et al.
Publicado: (2021)

Flavonoid glycosides and their putative human metabolites as potential inhibitors of the SARS-CoV-2 main protease (Mpro) and RNA-dependent RNA polymerase (RdRp)
por: da Silva, Felipe Moura A, et al.
Publicado: (2020)

Identification of 14 Known Drugs as Inhibitors of the Main Protease of SARS-CoV-2
por: Ghahremanpour, Mohammad M., et al.
Publicado: (2020)

Structural dynamics of COVID-19 main protease
por: Shekaari, Ashkan, et al.
Publicado: (2021)

Quaternary Structure of the SARS Coronavirus Main Protease
por: Chang, Gu-Gang
Publicado: (2009)

Allosteric inhibitors of the main protease of SARS-CoV-2
por: Samrat, Subodh Kumar, et al.
Publicado: (2022)

Computational fragment screening of dimeric SARS-CoV-2 main protease
por: Reid, Rashad L., et al.
Publicado: (2023)

Protease Activated Receptor 1 and Its Ligands as Main Regulators of the Regeneration of Peripheral Nerves
por: Pompili, Elena, et al.
Publicado: (2021)

Rational Design of Hybrid SARS-CoV-2 Main Protease Inhibitors Guided by the Superimposed Cocrystal Structures with the Peptidomimetic Inhibitors GC-376, Telaprevir, and Boceprevir
por: Xia, Zilei, et al.
Publicado: (2021)

Supercomputer simulation of the covalent inhibition of the main protease of SARS-CoV-2
por: Nemukhin, A. V., et al.
Publicado: (2022)

The Molecular Mechanism of Domain Swapping of the C-Terminal Domain of the SARS-Coronavirus Main Protease
por: Terse, Vishram L., et al.
Publicado: (2021)

Activation and maturation of SARS-CoV main protease
por: Xia, Bin, et al.
Publicado: (2011)

Individual and common inhibitors of coronavirus and picornavirus main proteases
por: Kuo, Chih-Jung, et al.
Publicado: (2009)

Enhancing the promiscuity of a member of the Caspase protease family by rational design
por: Öhlknecht, Christoph, et al.
Publicado: (2020)

Molecular characterization of ebselen binding activity to SARS-CoV-2 main protease
por: Menéndez, Cintia A., et al.
Publicado: (2020)

Molecular modeling evaluation of the binding effect of five protease inhibitors to COVID-19 main protease
por: Liu, Jian, et al.
Publicado: (2021)

Analysis of the efficacy of HIV protease inhibitors against SARS-CoV-2′s main protease
por: Mahdi, Mohamed, et al.
Publicado: (2020)

Calcifying Odontogenic Cyst with Extensive Areas of Dentinoid: Uncommon Case Report and Update of Main Findings
por: Santos, Hellen Bandeira de Pontes, et al.
Publicado: (2018)

2-Pyridone natural products as inhibitors of SARS-CoV-2 main protease
por: Forrestall, Katrina L., et al.
Publicado: (2021)

Rational use of chest ultrasound to confront COVID-19
por: Francisco Neto, Miguel José, et al.
Publicado: (2020)

Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases
por: Yang, Haitao, et al.
Publicado: (2005)

The SARS-CoV-2 main protease as drug target
por: Ullrich, Sven, et al.
Publicado: (2020)

Topological analysis of SARS CoV-2 main protease
por: Estrada, Ernesto
Publicado: (2020)

Developing inhibitors of the SARS-CoV-2 main protease
por: Seitz, Christian, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_cr10o61ikq626ehhbcq1j8k3r9