HLA-G Expressing Immune Cells in Immune Mediated Diseases

HLA-G is a HLA class Ib antigen that possesses immunomodulatory properties. HLA-G-expressing CD4+ and CD8+ T lymphocytes, NK cells, monocytes, and dendritic cells with immunoregulatory functions are present in small percentages of patients with physiologic conditions. Quantitative and qualitative de...

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Autores principales: Contini, P., Murdaca, Giuseppe, Puppo, Francesco, Negrini, Simone
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7484697/
https://www.ncbi.nlm.nih.gov/pubmed/32983083
http://dx.doi.org/10.3389/fimmu.2020.01613
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author Contini, P.
Murdaca, Giuseppe
Puppo, Francesco
Negrini, Simone
author_facet Contini, P.
Murdaca, Giuseppe
Puppo, Francesco
Negrini, Simone
author_sort Contini, P.
collection PubMed
description HLA-G is a HLA class Ib antigen that possesses immunomodulatory properties. HLA-G-expressing CD4+ and CD8+ T lymphocytes, NK cells, monocytes, and dendritic cells with immunoregulatory functions are present in small percentages of patients with physiologic conditions. Quantitative and qualitative derangements of HLA-G+ immune cells have been detected in several conditions in which the immune system plays an important role, such as infectious, neoplastic, and autoimmune diseases as well as in complications from transplants and pregnancy. These observations strongly support the hypothesis that HLA-G+ immune cells may be implicated in the complex mechanisms underlying the pathogenesis of these disorders.
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spelling pubmed-74846972020-09-24 HLA-G Expressing Immune Cells in Immune Mediated Diseases Contini, P. Murdaca, Giuseppe Puppo, Francesco Negrini, Simone Front Immunol Immunology HLA-G is a HLA class Ib antigen that possesses immunomodulatory properties. HLA-G-expressing CD4+ and CD8+ T lymphocytes, NK cells, monocytes, and dendritic cells with immunoregulatory functions are present in small percentages of patients with physiologic conditions. Quantitative and qualitative derangements of HLA-G+ immune cells have been detected in several conditions in which the immune system plays an important role, such as infectious, neoplastic, and autoimmune diseases as well as in complications from transplants and pregnancy. These observations strongly support the hypothesis that HLA-G+ immune cells may be implicated in the complex mechanisms underlying the pathogenesis of these disorders. Frontiers Media S.A. 2020-08-28 /pmc/articles/PMC7484697/ /pubmed/32983083 http://dx.doi.org/10.3389/fimmu.2020.01613 Text en Copyright © 2020 Contini, Murdaca, Puppo and Negrini. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Contini, P.
Murdaca, Giuseppe
Puppo, Francesco
Negrini, Simone
HLA-G Expressing Immune Cells in Immune Mediated Diseases
title HLA-G Expressing Immune Cells in Immune Mediated Diseases
title_full HLA-G Expressing Immune Cells in Immune Mediated Diseases
title_fullStr HLA-G Expressing Immune Cells in Immune Mediated Diseases
title_full_unstemmed HLA-G Expressing Immune Cells in Immune Mediated Diseases
title_short HLA-G Expressing Immune Cells in Immune Mediated Diseases
title_sort hla-g expressing immune cells in immune mediated diseases
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7484697/
https://www.ncbi.nlm.nih.gov/pubmed/32983083
http://dx.doi.org/10.3389/fimmu.2020.01613
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AT negrinisimone hlagexpressingimmunecellsinimmunemediateddiseases

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