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COVID-19 in a Severely Immunosuppressed Patient With Life-Threatening Eosinophilic Granulomatosis With Polyangiitis

Immunosuppressive therapies increase the susceptibility of patients to infections. The current pandemic with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) compels clinicians to develop recommendations for successful clinical management and surveillance of immunocompromised patients at...

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Autores principales: Schramm, Markus A., Venhoff, Nils, Wagner, Dirk, Thiel, Jens, Huzly, Daniela, Craig-Mueller, Nils, Panning, Marcus, Hengel, Hartmut, Kern, Winfried V., Voll, Reinhard E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7484740/
https://www.ncbi.nlm.nih.gov/pubmed/32983161
http://dx.doi.org/10.3389/fimmu.2020.02086
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author Schramm, Markus A.
Venhoff, Nils
Wagner, Dirk
Thiel, Jens
Huzly, Daniela
Craig-Mueller, Nils
Panning, Marcus
Hengel, Hartmut
Kern, Winfried V.
Voll, Reinhard E.
author_facet Schramm, Markus A.
Venhoff, Nils
Wagner, Dirk
Thiel, Jens
Huzly, Daniela
Craig-Mueller, Nils
Panning, Marcus
Hengel, Hartmut
Kern, Winfried V.
Voll, Reinhard E.
author_sort Schramm, Markus A.
collection PubMed
description Immunosuppressive therapies increase the susceptibility of patients to infections. The current pandemic with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) compels clinicians to develop recommendations for successful clinical management and surveillance of immunocompromised patients at high risk for severe disease progression. With only few case studies published on SARS-CoV-2 infection in patients with rheumatic diseases, we report a 25-year-old male who developed moderate coronavirus disease 2019 (COVID-19) with fever, mild dyspnea, and no major complications despite having received high-dose prednisolone, cyclophosphamide, and rituximab for the treatment of highly active, life-threatening eosinophilic granulomatosis with polyangiitis (EGPA).
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spelling pubmed-74847402020-09-24 COVID-19 in a Severely Immunosuppressed Patient With Life-Threatening Eosinophilic Granulomatosis With Polyangiitis Schramm, Markus A. Venhoff, Nils Wagner, Dirk Thiel, Jens Huzly, Daniela Craig-Mueller, Nils Panning, Marcus Hengel, Hartmut Kern, Winfried V. Voll, Reinhard E. Front Immunol Immunology Immunosuppressive therapies increase the susceptibility of patients to infections. The current pandemic with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) compels clinicians to develop recommendations for successful clinical management and surveillance of immunocompromised patients at high risk for severe disease progression. With only few case studies published on SARS-CoV-2 infection in patients with rheumatic diseases, we report a 25-year-old male who developed moderate coronavirus disease 2019 (COVID-19) with fever, mild dyspnea, and no major complications despite having received high-dose prednisolone, cyclophosphamide, and rituximab for the treatment of highly active, life-threatening eosinophilic granulomatosis with polyangiitis (EGPA). Frontiers Media S.A. 2020-08-28 /pmc/articles/PMC7484740/ /pubmed/32983161 http://dx.doi.org/10.3389/fimmu.2020.02086 Text en Copyright © 2020 Schramm, Venhoff, Wagner, Thiel, Huzly, Craig-Mueller, Panning, Hengel, Kern and Voll. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Schramm, Markus A.
Venhoff, Nils
Wagner, Dirk
Thiel, Jens
Huzly, Daniela
Craig-Mueller, Nils
Panning, Marcus
Hengel, Hartmut
Kern, Winfried V.
Voll, Reinhard E.
COVID-19 in a Severely Immunosuppressed Patient With Life-Threatening Eosinophilic Granulomatosis With Polyangiitis
title COVID-19 in a Severely Immunosuppressed Patient With Life-Threatening Eosinophilic Granulomatosis With Polyangiitis
title_full COVID-19 in a Severely Immunosuppressed Patient With Life-Threatening Eosinophilic Granulomatosis With Polyangiitis
title_fullStr COVID-19 in a Severely Immunosuppressed Patient With Life-Threatening Eosinophilic Granulomatosis With Polyangiitis
title_full_unstemmed COVID-19 in a Severely Immunosuppressed Patient With Life-Threatening Eosinophilic Granulomatosis With Polyangiitis
title_short COVID-19 in a Severely Immunosuppressed Patient With Life-Threatening Eosinophilic Granulomatosis With Polyangiitis
title_sort covid-19 in a severely immunosuppressed patient with life-threatening eosinophilic granulomatosis with polyangiitis
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7484740/
https://www.ncbi.nlm.nih.gov/pubmed/32983161
http://dx.doi.org/10.3389/fimmu.2020.02086
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