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Dysfunction of CD8 + PD-1 + T cells in type 2 diabetes caused by the impairment of metabolism-immune axis
The metabolic changes and dysfunction in CD8 + T cells may be involved in tumor progression and susceptibility to virus infection in type 2 diabetes (T2D). In C57BL/6JJcl mice fed with high fat-high sucrose chow (HFS), multifunctionality of CD8 + splenic and tumor-infiltrating lymphocytes (TILs) was...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7484782/ https://www.ncbi.nlm.nih.gov/pubmed/32913271 http://dx.doi.org/10.1038/s41598-020-71946-3 |
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author | Nojima, Ichiro Eikawa, Shingo Tomonobu, Nahoko Hada, Yoshiko Kajitani, Nobuo Teshigawara, Sanae Miyamoto, Satoshi Tone, Atsuhito Uchida, Haruhito A. Nakatsuka, Atsuko Eguchi, Jun Shikata, Kenichi Udono, Heiichiro Wada, Jun |
author_facet | Nojima, Ichiro Eikawa, Shingo Tomonobu, Nahoko Hada, Yoshiko Kajitani, Nobuo Teshigawara, Sanae Miyamoto, Satoshi Tone, Atsuhito Uchida, Haruhito A. Nakatsuka, Atsuko Eguchi, Jun Shikata, Kenichi Udono, Heiichiro Wada, Jun |
author_sort | Nojima, Ichiro |
collection | PubMed |
description | The metabolic changes and dysfunction in CD8 + T cells may be involved in tumor progression and susceptibility to virus infection in type 2 diabetes (T2D). In C57BL/6JJcl mice fed with high fat-high sucrose chow (HFS), multifunctionality of CD8 + splenic and tumor-infiltrating lymphocytes (TILs) was impaired and associated with enhanced tumor growth, which were inhibited by metformin. In CD8 + splenic T cells from the HFS mice, glycolysis/basal respiration ratio was significantly reduced and reversed by metformin. In the patients with T2D (DM), multifunctionality of circulating CD8 + PD-1 + T cells stimulated with PMA/ionomycin as well as with HLA-A*24:02 CMV peptide was dampened, while metformin recovered multifunctionality. Both glycolysis and basal respiration were reduced in DM, and glycolysis was increased by metformin. The disturbance of the link between metabolism and immune function in CD8 + PD-1 + T cells in T2D was proved by recovery of antigen-specific and non-specific cytokine production via metformin-mediated increase in glycolytic activity. |
format | Online Article Text |
id | pubmed-7484782 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-74847822020-09-15 Dysfunction of CD8 + PD-1 + T cells in type 2 diabetes caused by the impairment of metabolism-immune axis Nojima, Ichiro Eikawa, Shingo Tomonobu, Nahoko Hada, Yoshiko Kajitani, Nobuo Teshigawara, Sanae Miyamoto, Satoshi Tone, Atsuhito Uchida, Haruhito A. Nakatsuka, Atsuko Eguchi, Jun Shikata, Kenichi Udono, Heiichiro Wada, Jun Sci Rep Article The metabolic changes and dysfunction in CD8 + T cells may be involved in tumor progression and susceptibility to virus infection in type 2 diabetes (T2D). In C57BL/6JJcl mice fed with high fat-high sucrose chow (HFS), multifunctionality of CD8 + splenic and tumor-infiltrating lymphocytes (TILs) was impaired and associated with enhanced tumor growth, which were inhibited by metformin. In CD8 + splenic T cells from the HFS mice, glycolysis/basal respiration ratio was significantly reduced and reversed by metformin. In the patients with T2D (DM), multifunctionality of circulating CD8 + PD-1 + T cells stimulated with PMA/ionomycin as well as with HLA-A*24:02 CMV peptide was dampened, while metformin recovered multifunctionality. Both glycolysis and basal respiration were reduced in DM, and glycolysis was increased by metformin. The disturbance of the link between metabolism and immune function in CD8 + PD-1 + T cells in T2D was proved by recovery of antigen-specific and non-specific cytokine production via metformin-mediated increase in glycolytic activity. Nature Publishing Group UK 2020-09-10 /pmc/articles/PMC7484782/ /pubmed/32913271 http://dx.doi.org/10.1038/s41598-020-71946-3 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Nojima, Ichiro Eikawa, Shingo Tomonobu, Nahoko Hada, Yoshiko Kajitani, Nobuo Teshigawara, Sanae Miyamoto, Satoshi Tone, Atsuhito Uchida, Haruhito A. Nakatsuka, Atsuko Eguchi, Jun Shikata, Kenichi Udono, Heiichiro Wada, Jun Dysfunction of CD8 + PD-1 + T cells in type 2 diabetes caused by the impairment of metabolism-immune axis |
title | Dysfunction of CD8 + PD-1 + T cells in type 2 diabetes caused by the impairment of metabolism-immune axis |
title_full | Dysfunction of CD8 + PD-1 + T cells in type 2 diabetes caused by the impairment of metabolism-immune axis |
title_fullStr | Dysfunction of CD8 + PD-1 + T cells in type 2 diabetes caused by the impairment of metabolism-immune axis |
title_full_unstemmed | Dysfunction of CD8 + PD-1 + T cells in type 2 diabetes caused by the impairment of metabolism-immune axis |
title_short | Dysfunction of CD8 + PD-1 + T cells in type 2 diabetes caused by the impairment of metabolism-immune axis |
title_sort | dysfunction of cd8 + pd-1 + t cells in type 2 diabetes caused by the impairment of metabolism-immune axis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7484782/ https://www.ncbi.nlm.nih.gov/pubmed/32913271 http://dx.doi.org/10.1038/s41598-020-71946-3 |
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