Rac1 conditional deletion attenuates retinal ganglion cell apoptosis by accelerating autophagic flux in a mouse model of chronic ocular hypertension

Autophagy has a fundamental role in maintaining cell homeostasis. Although autophagy has been implicated in glaucomatous pathology, how it regulates retinal ganglion cell (RGC) injury is largely unknown. In the present work, we found that biphasic autophagy in RGCs occurred in a mouse model of chron...

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Detalles Bibliográficos
Autores principales: Zhang, Meng-Lu, Zhao, Guo-Li, Hou, Yu, Zhong, Shu-Min, Xu, Lin-Jie, Li, Fang, Niu, Wei-Ran, Yuan, Fei, Yang, Xiong-Li, Wang, Zhongfeng, Miao, Yanying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7484783/
https://www.ncbi.nlm.nih.gov/pubmed/32913260
http://dx.doi.org/10.1038/s41419-020-02951-7

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