Resolution of R-loops by INO80 promotes DNA replication and maintains cancer cell proliferation and viability

Collisions between the DNA replication machinery and co-transcriptional R-loops can impede DNA synthesis and are a major source of genomic instability in cancer cells. How cancer cells deal with R-loops to proliferate is poorly understood. Here we show that the ATP-dependent chromatin remodelling IN...

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Detalles Bibliográficos
Autores principales: Prendergast, Lisa, McClurg, Urszula L., Hristova, Rossitsa, Berlinguer-Palmini, Rolando, Greener, Sarah, Veitch, Katie, Hernandez, Inmaculada, Pasero, Philippe, Rico, Daniel, Higgins, Jonathan M. G., Gospodinov, Anastas, Papamichos-Chronakis, Manolis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7484789/
https://www.ncbi.nlm.nih.gov/pubmed/32913330
http://dx.doi.org/10.1038/s41467-020-18306-x

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