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MCL-1 gains occur with high frequency in lung adenocarcinoma and can be targeted therapeutically

Evasion of programmed cell death represents a critical form of oncogene addiction in cancer cells. Understanding the molecular mechanisms underpinning cancer cell survival despite the oncogenic stress could provide a molecular basis for potential therapeutic interventions. Here we explore the role o...

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Detalles Bibliográficos
Autores principales: Munkhbaatar, Enkhtsetseg, Dietzen, Michelle, Agrawal, Deepti, Anton, Martina, Jesinghaus, Moritz, Boxberg, Melanie, Pfarr, Nicole, Bidola, Pidassa, Uhrig, Sebastian, Höckendorf, Ulrike, Meinhardt, Anna-Lena, Wahida, Adam, Heid, Irina, Braren, Rickmer, Mishra, Ritu, Warth, Arne, Muley, Thomas, Poh, Patrina S. P., Wang, Xin, Fröhling, Stefan, Steiger, Katja, Slotta-Huspenina, Julia, van Griensven, Martijn, Pfeiffer, Franz, Lange, Sebastian, Rad, Roland, Spella, Magda, Stathopoulos, Georgios T., Ruland, Jürgen, Bassermann, Florian, Weichert, Wilko, Strasser, Andreas, Branca, Caterina, Heikenwalder, Mathias, Swanton, Charles, McGranahan, Nicholas, Jost, Philipp J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7484793/
https://www.ncbi.nlm.nih.gov/pubmed/32913197
http://dx.doi.org/10.1038/s41467-020-18372-1