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Investigation of tumor and vessel motion correlation in the liver

Intrafraction imaging‐based motion management systems for external beam radiotherapy can rely on internal surrogate structures when the target is not easily visualized. This work evaluated the validity of using liver vessels as internal surrogates for the estimation of liver tumor motion. Vessel and...

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Autores principales: Jupitz, Sydney A., Shepard, Andrew J., Hill, Patrick M., Bednarz, Bryan P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7484818/
https://www.ncbi.nlm.nih.gov/pubmed/32533758
http://dx.doi.org/10.1002/acm2.12943
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author Jupitz, Sydney A.
Shepard, Andrew J.
Hill, Patrick M.
Bednarz, Bryan P.
author_facet Jupitz, Sydney A.
Shepard, Andrew J.
Hill, Patrick M.
Bednarz, Bryan P.
author_sort Jupitz, Sydney A.
collection PubMed
description Intrafraction imaging‐based motion management systems for external beam radiotherapy can rely on internal surrogate structures when the target is not easily visualized. This work evaluated the validity of using liver vessels as internal surrogates for the estimation of liver tumor motion. Vessel and tumor motion were assessed using ten two‐dimensional sagittal MR cine datasets collected on the ViewRay MRIdian. For each case, a liver tumor and at least one vessel were tracked for 175 s. A tracking approach utilizing block matching and multiple simultaneous templates was applied. Accuracy of the tracked motion was calculated from the error between the tracked centroid position and manually defined ground truth annotations. The patient’s abdomen surface and diaphragm were manually annotated in all frames. The Pearson correlation coefficient (CC) was used to compare the motion of the features and tumor in the anterior–posterior (AP) and superior–inferior (SI) directions. The distance between the centroids of the features and the tumors was calculated to assess if feature proximity affects relative correlation, and the tumor range of motion was determined. Intra‐ and interfraction motion amplitude variabilities were evaluated to further assess the relationship between tumor and feature motion. The mean CC between the motion of the vessel and the tumor were 0.85 ± 0.11 (AP) and 0.92 ± 0.04 (SI), 0.83 ± 0.11 (AP) and −0.89 ± 0.06 (SI) for the surface and tumor, and 0.80 ± 0.17 (AP) and 0.94 ± 0.03 (SI) for the diaphragm and tumor. For intrafraction analysis, the average amplitude variability was 2.47 ± 0.77 mm (AP) and 3.14 ± 1.49 mm (SI) for the vessels, 2.70 ± 1.08 mm (AP) and 3.43 ± 1.73 mm (SI) for the surface, and 2.76 ± 1.41 mm (AP) and 2.91 ± 1.38 mm (SI) for the diaphragm. No relationship between distance and motion correlation was observed. The motion of liver tumors and liver vessels was well correlated, making vessels a suitable surrogate for tumor motion in the liver.
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spelling pubmed-74848182020-09-17 Investigation of tumor and vessel motion correlation in the liver Jupitz, Sydney A. Shepard, Andrew J. Hill, Patrick M. Bednarz, Bryan P. J Appl Clin Med Phys Radiation Oncology Physics Intrafraction imaging‐based motion management systems for external beam radiotherapy can rely on internal surrogate structures when the target is not easily visualized. This work evaluated the validity of using liver vessels as internal surrogates for the estimation of liver tumor motion. Vessel and tumor motion were assessed using ten two‐dimensional sagittal MR cine datasets collected on the ViewRay MRIdian. For each case, a liver tumor and at least one vessel were tracked for 175 s. A tracking approach utilizing block matching and multiple simultaneous templates was applied. Accuracy of the tracked motion was calculated from the error between the tracked centroid position and manually defined ground truth annotations. The patient’s abdomen surface and diaphragm were manually annotated in all frames. The Pearson correlation coefficient (CC) was used to compare the motion of the features and tumor in the anterior–posterior (AP) and superior–inferior (SI) directions. The distance between the centroids of the features and the tumors was calculated to assess if feature proximity affects relative correlation, and the tumor range of motion was determined. Intra‐ and interfraction motion amplitude variabilities were evaluated to further assess the relationship between tumor and feature motion. The mean CC between the motion of the vessel and the tumor were 0.85 ± 0.11 (AP) and 0.92 ± 0.04 (SI), 0.83 ± 0.11 (AP) and −0.89 ± 0.06 (SI) for the surface and tumor, and 0.80 ± 0.17 (AP) and 0.94 ± 0.03 (SI) for the diaphragm and tumor. For intrafraction analysis, the average amplitude variability was 2.47 ± 0.77 mm (AP) and 3.14 ± 1.49 mm (SI) for the vessels, 2.70 ± 1.08 mm (AP) and 3.43 ± 1.73 mm (SI) for the surface, and 2.76 ± 1.41 mm (AP) and 2.91 ± 1.38 mm (SI) for the diaphragm. No relationship between distance and motion correlation was observed. The motion of liver tumors and liver vessels was well correlated, making vessels a suitable surrogate for tumor motion in the liver. John Wiley and Sons Inc. 2020-06-13 /pmc/articles/PMC7484818/ /pubmed/32533758 http://dx.doi.org/10.1002/acm2.12943 Text en © 2020 The Authors. Journal of Applied Clinical Medical Physics published by Wiley Periodicals, Inc. on behalf of American Association of Physicists in Medicine. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Radiation Oncology Physics
Jupitz, Sydney A.
Shepard, Andrew J.
Hill, Patrick M.
Bednarz, Bryan P.
Investigation of tumor and vessel motion correlation in the liver
title Investigation of tumor and vessel motion correlation in the liver
title_full Investigation of tumor and vessel motion correlation in the liver
title_fullStr Investigation of tumor and vessel motion correlation in the liver
title_full_unstemmed Investigation of tumor and vessel motion correlation in the liver
title_short Investigation of tumor and vessel motion correlation in the liver
title_sort investigation of tumor and vessel motion correlation in the liver
topic Radiation Oncology Physics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7484818/
https://www.ncbi.nlm.nih.gov/pubmed/32533758
http://dx.doi.org/10.1002/acm2.12943
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