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Integrating genetic and nongenetic drivers of somatic evolution during carcinogenesis: The biplane model
The multistep transition from a normal to a malignant cellular phenotype is often termed “somatic evolution” caused by accumulating random mutations. Here, we propose an alternative model in which the initial genetic state of a cancer cell is the result of mutations that occurred throughout the life...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7484850/ https://www.ncbi.nlm.nih.gov/pubmed/32952610 http://dx.doi.org/10.1111/eva.12973 |