Immune Modulation as a Therapeutic Option During the SARS-CoV-2 Outbreak: The Case for Antimalarial Aminoquinolines

The rapid spread, severity, and lack of specific treatment for COVID-19 resulted in hasty drug repurposing. Conceptually, trials of antivirals were well-accepted, but twentieth century antimalarials sparked an impassioned global debate. Notwithstanding, antiviral and immunomodulatory effects of amin...

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Autores principales: Vitte, Joana, Michel, Moïse, Mezouar, Soraya, Diallo, Aïssatou Bailo, Boumaza, Asma, Mege, Jean-Louis, Desnues, Benoit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7484884/
https://www.ncbi.nlm.nih.gov/pubmed/32983179
http://dx.doi.org/10.3389/fimmu.2020.02159
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author Vitte, Joana
Michel, Moïse
Mezouar, Soraya
Diallo, Aïssatou Bailo
Boumaza, Asma
Mege, Jean-Louis
Desnues, Benoit
author_facet Vitte, Joana
Michel, Moïse
Mezouar, Soraya
Diallo, Aïssatou Bailo
Boumaza, Asma
Mege, Jean-Louis
Desnues, Benoit
author_sort Vitte, Joana
collection PubMed
description The rapid spread, severity, and lack of specific treatment for COVID-19 resulted in hasty drug repurposing. Conceptually, trials of antivirals were well-accepted, but twentieth century antimalarials sparked an impassioned global debate. Notwithstanding, antiviral and immunomodulatory effects of aminoquinolines have been investigated in vitro, in vivo and in clinical trials for more than 30 years. We review the mechanisms of action of (hydroxy)chloroquine on immune cells and networks and discuss promises and pitfalls in the fight against SARS-CoV-2, the agent of the COVID-19 outbreak.
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spelling pubmed-74848842020-09-24 Immune Modulation as a Therapeutic Option During the SARS-CoV-2 Outbreak: The Case for Antimalarial Aminoquinolines Vitte, Joana Michel, Moïse Mezouar, Soraya Diallo, Aïssatou Bailo Boumaza, Asma Mege, Jean-Louis Desnues, Benoit Front Immunol Immunology The rapid spread, severity, and lack of specific treatment for COVID-19 resulted in hasty drug repurposing. Conceptually, trials of antivirals were well-accepted, but twentieth century antimalarials sparked an impassioned global debate. Notwithstanding, antiviral and immunomodulatory effects of aminoquinolines have been investigated in vitro, in vivo and in clinical trials for more than 30 years. We review the mechanisms of action of (hydroxy)chloroquine on immune cells and networks and discuss promises and pitfalls in the fight against SARS-CoV-2, the agent of the COVID-19 outbreak. Frontiers Media S.A. 2020-08-28 /pmc/articles/PMC7484884/ /pubmed/32983179 http://dx.doi.org/10.3389/fimmu.2020.02159 Text en Copyright © 2020 Vitte, Michel, Mezouar, Diallo, Boumaza, Mege and Desnues. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Vitte, Joana
Michel, Moïse
Mezouar, Soraya
Diallo, Aïssatou Bailo
Boumaza, Asma
Mege, Jean-Louis
Desnues, Benoit
Immune Modulation as a Therapeutic Option During the SARS-CoV-2 Outbreak: The Case for Antimalarial Aminoquinolines
title Immune Modulation as a Therapeutic Option During the SARS-CoV-2 Outbreak: The Case for Antimalarial Aminoquinolines
title_full Immune Modulation as a Therapeutic Option During the SARS-CoV-2 Outbreak: The Case for Antimalarial Aminoquinolines
title_fullStr Immune Modulation as a Therapeutic Option During the SARS-CoV-2 Outbreak: The Case for Antimalarial Aminoquinolines
title_full_unstemmed Immune Modulation as a Therapeutic Option During the SARS-CoV-2 Outbreak: The Case for Antimalarial Aminoquinolines
title_short Immune Modulation as a Therapeutic Option During the SARS-CoV-2 Outbreak: The Case for Antimalarial Aminoquinolines
title_sort immune modulation as a therapeutic option during the sars-cov-2 outbreak: the case for antimalarial aminoquinolines
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7484884/
https://www.ncbi.nlm.nih.gov/pubmed/32983179
http://dx.doi.org/10.3389/fimmu.2020.02159
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