Liver-Specific Knockdown of Class IIa HDACs Has Limited Efficacy on Glucose Metabolism but Entails Severe Organ Side Effects in Mice

Histone deacetylases (HDACs) are important regulators of epigenetic gene modification that are involved in the transcriptional control of metabolism. In particular class IIa HDACs have been shown to affect hepatic gluconeogenesis and previous approaches revealed that their inhibition reduces blood g...

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Detalles Bibliográficos
Autores principales: Ziegler, Nicole, Raichur, Suryaprakash, Brunner, Bodo, Hemmann, Ulrike, Stolte, Manuela, Schwahn, Uwe, Prochnow, Hans-Peter, Metz-Weidmann, Christiane, Tennagels, Norbert, Margerie, Daniel, Wohlfart, Paulus, Bielohuby, Maximilian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7485437/
https://www.ncbi.nlm.nih.gov/pubmed/32982982
http://dx.doi.org/10.3389/fendo.2020.00598

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