Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits

Problematic alcohol use (PAU) is a leading cause of death and disability worldwide. Although genome-wide association studies (GWASs) have identified PAU risk genes, the genetic architecture of this trait is not fully understood. We conducted a proxy-phenotype meta-analysis of PAU combining alcohol u...

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Detalles Bibliográficos
Autores principales: Zhou, Hang, Sealock, Julia M., Sanchez-Roige, Sandra, Clarke, Toni-Kim, Levey, Daniel F., Cheng, Zhongshan, Li, Boyang, Polimanti, Renato, Kember, Rachel L., Smith, Rachel Vickers, Thygesen, Johan H., Morgan, Marsha Y., Atkinson, Stephen R., Thursz, Mark R., Nyegaard, Mette, Mattheisen, Manuel, Børglum, Anders D., Johnson, Emma C., Justice, Amy C., Palmer, Abraham A., McQuillin, Andrew, Davis, Lea K., Edenberg, Howard J., Agrawal, Arpana, Kranzler, Henry R., Gelernter, Joel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7485556/
https://www.ncbi.nlm.nih.gov/pubmed/32451486
http://dx.doi.org/10.1038/s41593-020-0643-5

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