Prolonged treatment with Y-27632 promotes the senescence of primary human dermal fibroblasts by increasing the expression of IGFBP-5 and transforming them into a CAF-like phenotype

The Rho-kinases (ROCK) inhibitor Y-27632 has been shown to promote the growth of epidermal cells, however, its potential effects on human dermal fibroblasts (HDFs) need to be clarified. Here we show that prolonged treatment of HDFs with Y-27632 decreased their growth by inducing senescence, which wa...

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Detalles Bibliográficos
Autores principales: Li, Xiangyong, Zhou, Qian, Wang, Shuangshuang, Wang, Ping, Li, Juan, Xie, Zhiwei, Liu, Chang, Wen, Jie, Wu, Xunwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7485707/
https://www.ncbi.nlm.nih.gov/pubmed/32843583
http://dx.doi.org/10.18632/aging.103910

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