Cargando…

Testosterone ameliorates vascular aging via the Gas6/Axl signaling pathway

Low serum testosterone level is associated with aging-related vascular stiffness, but the underlying mechanism is unclear. The Growth arrest-specific protein 6 (Gas6) /Axl pathway has been proved to play important roles in cell senescence. In this study, we intend to explore whether Gas6/Axl is invo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Yan-Qing, Zhou, Hui-Min, Chen, Fang-Fang, Liu, Ya-Peng, Han, Lu, Song, Ming, Wang, Zhi-Hao, Zhang, Wei, Shang, Yuan-Yuan, Zhong, Ming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals 2020
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7485733/ https://www.ncbi.nlm.nih.gov/pubmed/32717722 http://dx.doi.org/10.18632/aging.103584

Ejemplares similares

Macrophage phenotypes and Gas6/Axl signaling in apical lesions
por: Chen, Szu-Yu, et al.
Publicado: (2019)

Gas6/Axl Signaling Pathway in the Tumor Immune Microenvironment
por: Tanaka, Mai, et al.
Publicado: (2020)

Therapeutic Targeting of the Gas6/Axl Signaling Pathway in Cancer
por: Tanaka, Mai, et al.
Publicado: (2021)

Gas6/AXL pathway: immunological landscape and therapeutic potential
por: Zhai, Xiaoqian, et al.
Publicado: (2023)

Gas6/Axl in arginine-starvation therapy
por: Tsai, Wen-Bin, et al.
Publicado: (2015)

Corosolic Acid Attenuates the Invasiveness of Glioblastoma Cells by Promoting CHIP-Mediated AXL Degradation and Inhibiting GAS6/AXL/JAK Axis
por: Sun, Li-Wei, et al.
Publicado: (2021)

NTNG1 Modulates Cisplatin Resistance in Epithelial Ovarian Cancer Cells via the GAS6/AXL/Akt Pathway
por: Fang, Shanyu, et al.
Publicado: (2021)

α-Lipoic acid attenuates vascular calcification via reversal of mitochondrial function and restoration of Gas6/Axl/Akt survival pathway
por: Kim, Hyunsoo, et al.
Publicado: (2012)

Gas6 Attenuates Sepsis-Induced Tight Junction Injury and Vascular Endothelial Hyperpermeability via the Axl/NF-κB Signaling Pathway
por: Ni, Jingjing, et al.
Publicado: (2019)

Gas6 Inhibits Toll-Like Receptor-Mediated Inflammatory Pathways in Mouse Microglia via Axl and Mer
por: Gilchrist, Shannon E., et al.
Publicado: (2020)

PGF2α-FP Receptor Ameliorates Senescence of VSMCs in Vascular Remodeling by Src/PAI-1 Signal Pathway
por: Hu, Bo-ang, et al.
Publicado: (2022)

Immunological Aspects of AXL/GAS‐6 in the Context of Human Liver Regeneration
por: Ortmayr, Gregor, et al.
Publicado: (2021)

AXL/Gas6 signaling mechanisms in the hypothalamic-pituitary-gonadal axis
por: Mohammadzadeh, Pardis, et al.
Publicado: (2023)

The prognostic role of Gas6/Axl axis in solid malignancies: a meta-analysis and literature review
por: Zhang, Sheng, et al.
Publicado: (2018)

Endocytic trafficking of GAS6–AXL complexes is associated with sustained AKT activation
por: Poświata, Agata, et al.
Publicado: (2022)

Gas6/Axl Axis Contributes to Chemoresistance and Metastasis in Breast Cancer through Akt/GSK-3β/β-catenin Signaling
por: Wang, Cun, et al.
Publicado: (2016)

Effect of GAS6 and AXL Gene Polymorphisms on Adiposity, Systemic Inflammation, and Insulin Resistance in Adolescents
por: Hsiao, Fone-Ching, et al.
Publicado: (2014)

Gas6 and the Receptor Tyrosine Kinase Axl in Clear Cell Renal Cell Carcinoma
por: Gustafsson, Anna, et al.
Publicado: (2009)

Chemotherapy-induced infiltration of neutrophils promotes pancreatic cancer metastasis via Gas6/AXL signalling axis
por: Bellomo, Gaia, et al.
Publicado: (2022)

Blockade of Axl signaling ameliorates HPV16E6-mediated tumorigenecity of cervical cancer
por: Lee, Eun-Hee, et al.
Publicado: (2017)

Neuroprotective Effects of Omentin-1 Against Cerebral Hypoxia/Reoxygenation Injury via Activating GAS6/Axl Signaling Pathway in Neuroblastoma Cells
por: Niu, Xiaochen, et al.
Publicado: (2022)

Plasma concentrations of Gas6 and sAxl correlate with disease activity in systemic lupus erythematosus
por: Ekman, Carl, et al.
Publicado: (2011)

Qigesan reduces the motility of esophageal cancer cells via inhibiting Gas6/Axl and NF-κB expression
por: Kong, Lingyu, et al.
Publicado: (2019)

Gas6/Axl signaling attenuates alveolar inflammation in ischemia-reperfusion-induced acute lung injury by up-regulating SOCS3-mediated pathway
por: Peng, Chung-Kan, et al.
Publicado: (2019)

Qigesan inhibits esophageal cancer cell invasion and migration by inhibiting Gas6/Axl-induced epithelial-mesenchymal transition
por: Kong, Lingyu, et al.
Publicado: (2020)

Pericyte FAK negatively regulates Gas6/Axl signalling to suppress tumour angiogenesis and tumour growth
por: Lechertier, Tanguy, et al.
Publicado: (2020)

A Functional Role of GAS6/TAM in Nonalcoholic Steatohepatitis Progression Implicates AXL as Therapeutic Target
por: Tutusaus, Anna, et al.
Publicado: (2019)

Decreased Gas6 and sAxl Plasma Levels Are Associated with Hair Loss in COVID-19 Survivors
por: Apostolo, Daria, et al.
Publicado: (2023)

DAPK and CIP2A are involved in GAS6/AXL-mediated Schwann cell proliferation in a rat model of bilateral cavernous nerve injury
por: Chen, Yen-Lin, et al.
Publicado: (2018)

The actin modulator hMENA regulates GAS6‐AXL axis and pro‐tumor cancer/stromal cell cooperation
por: Melchionna, Roberta, et al.
Publicado: (2020)

Vitamin K Effects on Gas6 and Soluble Axl Receptors in Intensive Care Patients: An Observational Screening Study
por: Schött, Ulf, et al.
Publicado: (2021)

Gas6/Axl Axis Activation Dampens the Inflammatory Response in Osteoarthritic Fibroblast-like Synoviocytes and Synovial Explants
por: Vago, Juliana P., et al.
Publicado: (2023)

PRAME Is a Novel Target of Tumor-Intrinsic Gas6/Axl Activation and Promotes Cancer Cell Invasion in Hepatocellular Carcinoma
por: Hedrich, Viola, et al.
Publicado: (2023)

Giving AXL the axe: targeting AXL in human malignancy
por: Gay, Carl M, et al.
Publicado: (2017)

AXL–GAS6 expression can predict for adverse prognosis in non-small cell lung cancer with brain metastases
por: Wu, Xiaoliang, et al.
Publicado: (2017)

GAS6/Axl Signaling Modulates Blood-Brain Barrier Function Following Intravenous Thrombolysis in Acute Ischemic Stroke
por: Guo, Zhen-Ni, et al.
Publicado: (2021)

AXL Expression on Homeostatic Resident Liver Macrophages Is Reduced in Cirrhosis Following GAS6 Production by Hepatic Stellate Cells
por: Pop, Oltin-Tiberiu, et al.
Publicado: (2023)

Author Correction: Pericyte FAK negatively regulates Gas6/Axl signalling to suppress tumour angiogenesis and tumour growth
por: Lechertier, Tanguy, et al.
Publicado: (2023)

Exosomes derived from BMSCs ameliorate cyclophosphamide-induced testosterone deficiency by enhancing the autophagy of Leydig cells via the AMPK-mTOR signaling pathway
por: Liang, Hao-Yu, et al.
Publicado: (2022)

Collaboration Between RSK-EphA2 and Gas6-Axl RTK Signaling in Arginine Starvation Response That Confers Resistance to EGFR Inhibitors
por: Kuo, Macus Tien, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_n6cvnv1vj5r5m209ttlnsa9gbr