Culture density contributes to hepatic functions of fresh human hepatocytes isolated from chimeric mice with humanized livers: Novel, long-term, functional two-dimensional in vitro tool for developing new drugs

Chimeric mice with humanized livers are considered a useful animal model for predicting human (h-) drug metabolism and toxicity. In this study, the characteristics of fresh h-hepatocytes (cFHHs, PXB-cells(®)) isolated from chimeric mice (PXB-mice(®)) were evaluated in vitro to confirm their utility...

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Detalles Bibliográficos
Autores principales: Yamasaki, Chihiro, Ishida, Yuji, Yanagi, Ami, Yoshizane, Yasumi, Kojima, Yuha, Ogawa, Yuko, Kageyama, Yutaka, Iwasaki, Yumiko, Ishida, Seiichi, Chayama, Kazuaki, Tateno, Chise
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7485858/
https://www.ncbi.nlm.nih.gov/pubmed/32915792
http://dx.doi.org/10.1371/journal.pone.0237809

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