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Improved glycaemic variability and basal insulin dose reduction during a running competition in recreationally active adults with type 1 diabetes—A single-centre, prospective, controlled observational study

INTRODUCTION: To investigate the glycaemic response, macronutrient intake and insulin management in people with type 1 diabetes (T1D) compared to healthy individuals around a running competition. MATERIAL AND METHODS: This was a single-centre, prospective, controlled observational study performed in...

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Autores principales: Moser, Othmar, Mueller, Alexander, Eckstein, Max L., Ziko, Haris, Aberer, Felix, Treiber, Gerlies, Unteregger, Christina, Kojzar, Harald, Mader, Julia K., Sourij, Caren, Pferschy, Peter, Obermayer, Anna, Tripolt, Norbert, Sourij, Harald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7485886/
https://www.ncbi.nlm.nih.gov/pubmed/32915897
http://dx.doi.org/10.1371/journal.pone.0239091
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author Moser, Othmar
Mueller, Alexander
Eckstein, Max L.
Ziko, Haris
Aberer, Felix
Treiber, Gerlies
Unteregger, Christina
Kojzar, Harald
Mader, Julia K.
Sourij, Caren
Pferschy, Peter
Obermayer, Anna
Tripolt, Norbert
Sourij, Harald
author_facet Moser, Othmar
Mueller, Alexander
Eckstein, Max L.
Ziko, Haris
Aberer, Felix
Treiber, Gerlies
Unteregger, Christina
Kojzar, Harald
Mader, Julia K.
Sourij, Caren
Pferschy, Peter
Obermayer, Anna
Tripolt, Norbert
Sourij, Harald
author_sort Moser, Othmar
collection PubMed
description INTRODUCTION: To investigate the glycaemic response, macronutrient intake and insulin management in people with type 1 diabetes (T1D) compared to healthy individuals around a running competition. MATERIAL AND METHODS: This was a single-centre, prospective, controlled observational study performed in individuals with T1D and healthy people. 24 people (12 T1D) were included in this study (age: T1D 41±12 vs. healthy 38±6 years, females: 3 vs. 6, BMI: 25.53.0 vs. 22.9±2.8 kg/m(2)). Both groups received an intermittently scanned continuous glucose monitoring (isCGM; FreeStyle Libre 1, Abbott, USA) system to assess glycaemia 24 hours before, during and 24 hours after a running competition. During this period, participants recorded their food intake and insulin administration. Data were analysed via ANOVA and mixed model analyses with post-hoc testing (p≤0.05). RESULTS: For overall glycaemic ranges in comparison of groups, significant differences were found for time in range (T1D 63±21% vs. healthy 89±13%, p = 0.001), time above range (TAR) 1 (T1D 21±15% vs. healthy 0±0%, p<0.001) and TAR 2 (T1D 8 [0–16%] vs. healthy 0±0%, p<0.001). When glycaemic variability was assessed, people with T1D had a higher glycaemic variability compared to healthy individuals (p<0.0001). Basal insulin dose was significantly reduced when compared against the regular pre-study basal insulin dose (pre-study 22±6 vs. pre-competition day 11±9 (-50±41%), p = 0.02; competition day 15±5 (-32± 1%)). CONCLUSION: People with T1D have impaired glucose responses around a running competition compared to healthy individuals. However, basal insulin dose reductions were sufficient to prevent further dysglycaemia. CLINICAL TRIAL ID: drks.de; DRKS00019886
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spelling pubmed-74858862020-09-21 Improved glycaemic variability and basal insulin dose reduction during a running competition in recreationally active adults with type 1 diabetes—A single-centre, prospective, controlled observational study Moser, Othmar Mueller, Alexander Eckstein, Max L. Ziko, Haris Aberer, Felix Treiber, Gerlies Unteregger, Christina Kojzar, Harald Mader, Julia K. Sourij, Caren Pferschy, Peter Obermayer, Anna Tripolt, Norbert Sourij, Harald PLoS One Research Article INTRODUCTION: To investigate the glycaemic response, macronutrient intake and insulin management in people with type 1 diabetes (T1D) compared to healthy individuals around a running competition. MATERIAL AND METHODS: This was a single-centre, prospective, controlled observational study performed in individuals with T1D and healthy people. 24 people (12 T1D) were included in this study (age: T1D 41±12 vs. healthy 38±6 years, females: 3 vs. 6, BMI: 25.53.0 vs. 22.9±2.8 kg/m(2)). Both groups received an intermittently scanned continuous glucose monitoring (isCGM; FreeStyle Libre 1, Abbott, USA) system to assess glycaemia 24 hours before, during and 24 hours after a running competition. During this period, participants recorded their food intake and insulin administration. Data were analysed via ANOVA and mixed model analyses with post-hoc testing (p≤0.05). RESULTS: For overall glycaemic ranges in comparison of groups, significant differences were found for time in range (T1D 63±21% vs. healthy 89±13%, p = 0.001), time above range (TAR) 1 (T1D 21±15% vs. healthy 0±0%, p<0.001) and TAR 2 (T1D 8 [0–16%] vs. healthy 0±0%, p<0.001). When glycaemic variability was assessed, people with T1D had a higher glycaemic variability compared to healthy individuals (p<0.0001). Basal insulin dose was significantly reduced when compared against the regular pre-study basal insulin dose (pre-study 22±6 vs. pre-competition day 11±9 (-50±41%), p = 0.02; competition day 15±5 (-32± 1%)). CONCLUSION: People with T1D have impaired glucose responses around a running competition compared to healthy individuals. However, basal insulin dose reductions were sufficient to prevent further dysglycaemia. CLINICAL TRIAL ID: drks.de; DRKS00019886 Public Library of Science 2020-09-11 /pmc/articles/PMC7485886/ /pubmed/32915897 http://dx.doi.org/10.1371/journal.pone.0239091 Text en © 2020 Moser et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Moser, Othmar
Mueller, Alexander
Eckstein, Max L.
Ziko, Haris
Aberer, Felix
Treiber, Gerlies
Unteregger, Christina
Kojzar, Harald
Mader, Julia K.
Sourij, Caren
Pferschy, Peter
Obermayer, Anna
Tripolt, Norbert
Sourij, Harald
Improved glycaemic variability and basal insulin dose reduction during a running competition in recreationally active adults with type 1 diabetes—A single-centre, prospective, controlled observational study
title Improved glycaemic variability and basal insulin dose reduction during a running competition in recreationally active adults with type 1 diabetes—A single-centre, prospective, controlled observational study
title_full Improved glycaemic variability and basal insulin dose reduction during a running competition in recreationally active adults with type 1 diabetes—A single-centre, prospective, controlled observational study
title_fullStr Improved glycaemic variability and basal insulin dose reduction during a running competition in recreationally active adults with type 1 diabetes—A single-centre, prospective, controlled observational study
title_full_unstemmed Improved glycaemic variability and basal insulin dose reduction during a running competition in recreationally active adults with type 1 diabetes—A single-centre, prospective, controlled observational study
title_short Improved glycaemic variability and basal insulin dose reduction during a running competition in recreationally active adults with type 1 diabetes—A single-centre, prospective, controlled observational study
title_sort improved glycaemic variability and basal insulin dose reduction during a running competition in recreationally active adults with type 1 diabetes—a single-centre, prospective, controlled observational study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7485886/
https://www.ncbi.nlm.nih.gov/pubmed/32915897
http://dx.doi.org/10.1371/journal.pone.0239091
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