Cargando…

Antimicrobial Peptide Omiganan Enhances Interferon Responses to Endosomal Toll‐Like Receptor Ligands in Human Peripheral Blood Mononuclear Cells

LL‐37 is a cationic antimicrobial peptide and the sole human member of cathelicidins. Besides its bactericidal properties, LL‐37 is known to have direct immunomodulatory effects, among which enhancement of antiviral responses via endosomal toll‐like receptors (TLRs). Omiganan pentahydrochloride is a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Grievink, Hendrika W., Jirka, Silvana M. G., Woutman, Tess D., Schoonakker, Mascha, Rissmann, Robert, Malone, Karen E., Feiss, Gary, Moerland, Matthijs
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7485948/ https://www.ncbi.nlm.nih.gov/pubmed/32314872 http://dx.doi.org/10.1111/cts.12789

Ejemplares similares

Omiganan Enhances Imiquimod‐Induced Inflammatory Responses in Skin of Healthy Volunteers
por: Niemeyer‐van der Kolk, Tessa, et al.
Publicado: (2020)

Clinical, Cellular, and Molecular Effects of Corticosteroids on the Response to Intradermal Lipopolysaccharide Administration in Healthy Volunteers
por: Buters, Thomas P., et al.
Publicado: (2022)

Immunosuppression by hydroxychloroquine: mechanistic proof in in vitro experiments but limited systemic activity in a randomized placebo-controlled clinical pharmacology study
por: in ‘t Veld, Aliede E., et al.
Publicado: (2023)

Pharmacodynamic Effects of Topical Omiganan in Patients With Mild to Moderate Atopic Dermatitis in a Randomized, Placebo‐Controlled, Phase II Trial
por: Niemeyer‐van der Kolk, Tessa, et al.
Publicado: (2020)

Intradermal lipopolysaccharide challenge as an acute in vivo inflammatory model in healthy volunteers
por: Buters, Thomas P., et al.
Publicado: (2021)

Treatment with the Topical Antimicrobial Peptide Omiganan in Mild-to-Moderate Facial Seborrheic Dermatitis versus Ketoconazole and Placebo: Results of a Randomized Controlled Proof-of-Concept Trial
por: Rousel, Jannik, et al.
Publicado: (2023)

Anticandidal Activity of Omiganan and Its Retro Analog Alone and in Combination with Fluconazole
por: Czechowicz, Paulina, et al.
Publicado: (2021)

Whole blood assay as a model for in vitro evaluation of inflammasome activation and subsequent caspase-mediated interleukin-1 beta release
por: Tran, Thi Anh Thu, et al.
Publicado: (2019)

Impact of oral administration of single strain Lactococcus lactis spp. cremoris on immune responses to keyhole limpet hemocyanin immunization and gut microbiota: A randomized placebo-controlled trial in healthy volunteers
por: Saghari, Mahdi, et al.
Publicado: (2022)

The Effect of a 13-Valent Conjugate Pneumococcal Vaccine on Circulating Antibodies Against Oxidized LDL and Phosphorylcholine in Man, A Randomized Placebo-Controlled Clinical Trial
por: Grievink, Hendrika W., et al.
Publicado: (2020)

The Antimicrobial Activity of Omiganan Alone and In Combination against Candida Isolated from Vulvovaginal Candidiasis and Bloodstream Infections
por: Żyrek, Dawid, et al.
Publicado: (2021)

Host genetics and tumor environment determine the functional impact of neutrophils in mouse tumor models
por: van Elsas, Marit, et al.
Publicado: (2020)

The Toll for Trafficking: Toll-Like Receptor 7 Delivery to the Endosome
por: Petes, Carlene, et al.
Publicado: (2017)

Blueprint for mechanistic, data‐rich early phase clinical pharmacology studies in dermatology
por: Rissmann, Robert, et al.
Publicado: (2020)

OX40L Inhibition Suppresses KLH‐driven Immune Responses in Healthy Volunteers: A Randomized Controlled Trial Demonstrating Proof‐of‐Pharmacology for KY1005
por: Saghari, Mahdi, et al.
Publicado: (2022)

Sample Aging Profoundly Reduces Monocyte Responses in Human Whole Blood Cultures
por: Grievink, H. W., et al.
Publicado: (2018)

Delivery of ligands from sorting endosomes to late endosomes occurs by maturation of sorting endosomes
Publicado: (1992)

Comprehensive, Multimodal Characterization of an Imiquimod‐Induced Human Skin Inflammation Model for Drug Development
por: van der Kolk, Tessa, et al.
Publicado: (2018)

HIV and HCV Activate the Inflammasome in Monocytes and Macrophages via Endosomal Toll-Like Receptors without Induction of Type 1 Interferon
por: Chattergoon, Michael A., et al.
Publicado: (2014)

Monitoring of Ex Vivo Cyclosporin a Activity in Healthy Volunteers Using T Cell Function Assays in Relation to Whole Blood and Cellular Pharmacokinetics
por: in ’t Veld, Aliede E., et al.
Publicado: (2022)

Emerging Role of Endosomal Toll-Like Receptors in Rheumatoid Arthritis
por: Thwaites, Ryan, et al.
Publicado: (2014)

Nucleic Acid Sensing by Toll-Like Receptors in the Endosomal Compartment
por: Miyake, Kensuke, et al.
Publicado: (2022)

Toll-like receptor 2–dependent endosomal signaling by Staphylococcus aureus in monocytes induces type I interferon and promotes intracellular survival
por: Musilova, Jana, et al.
Publicado: (2019)

Stimulation of the PD-1 Pathway Decreases Atherosclerotic Lesion Development in Ldlr Deficient Mice
por: Grievink, Hendrika W., et al.
Publicado: (2021)

Toll-Like Receptor Ligands and Interferon-γ Synergize for Induction of Antitumor M1 Macrophages
por: Müller, Elisabeth, et al.
Publicado: (2017)

Immunomonitoring of Tacrolimus in Healthy Volunteers: The First Step from PK- to PD-Based Therapeutic Drug Monitoring?
por: in ‘t Veld, Aliede E., et al.
Publicado: (2019)

Natural Modulators of Endosomal Toll-Like Receptor-Mediated Psoriatic Skin Inflammation
por: Lai, Chao-Yang, et al.
Publicado: (2017)

Participation of Endosomes in Toll-Like Receptor 3 Transportation Pathway in Murine Astrocytes
por: Mielcarska, Matylda B., et al.
Publicado: (2020)

Innate and Adaptive Responses of Intratumoral Immunotherapy with Endosomal Toll-Like Receptor Agonists
por: Andón, Fernando Torres, et al.
Publicado: (2022)

Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands
por: Barbalat, Roman, et al.
Publicado: (2009)

Toll-like receptor ligands induce the expression of interferon-gamma and interleukin-17 in chicken CD4+ T cells
por: St Paul, Michael, et al.
Publicado: (2012)

Modifications of the endosomal compartment in peripheral blood mononuclear cells and fibroblasts from Alzheimer's disease patients
por: Corlier, F, et al.
Publicado: (2015)

Toll-Like Receptors, Their Ligands, and Atherosclerosis
por: Hodgkinson, Conrad P., et al.
Publicado: (2011)

Integration of healthy volunteers in early phase clinical trials with immuno-oncological compounds
por: Radanovic, Igor, et al.
Publicado: (2022)

Involvement of M1 Macrophage Polarization in Endosomal Toll-Like Receptors Activated Psoriatic Inflammation
por: Lu, Chih-Hao, et al.
Publicado: (2018)

Cell Surface Expression of Endosomal Toll-Like Receptors—A Necessity or a Superfluous Duplication?
por: Mielcarska, Matylda Barbara, et al.
Publicado: (2021)

The interferon inducible isoform of NCOA7 inhibits endosome-mediated viral entry
por: Doyle, Tomas, et al.
Publicado: (2018)

Interferon‐inducible phospholipids govern IFITM3‐dependent endosomal antiviral immunity
por: Unali, Giulia, et al.
Publicado: (2023)

Interferon-α and Interleukin-12 Are Induced Differentially by Toll-like Receptor 7 Ligands in Human Blood Dendritic Cell Subsets
por: Ito, Tomoki, et al.
Publicado: (2002)

Comprehensive evaluation of microneedle‐based intradermal adalimumab delivery vs. subcutaneous administration: results of a randomized controlled clinical trial
por: Jacobse, Justin, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_a45nso8n6vun7cfbmniqblkd1g