­­A high-throughput screen identifies inhibitors of the interaction between the oncogenic transcription factor ERG and the cofactor EWS

Aberrant expression of the transcription factor ERG is a key driving event in approximately one-half of all of prostate cancers. Lacking an enzymatic pocket and mainly disordered, the structure of ERG is difficult to exploit for therapeutic design. We recently identified EWS as a specific interactin...

Descripción completa

Detalles Bibliográficos
Autores principales: Nicholas, Taylor R., Meng, Jingwei, Greulich, Benjamin M., Morris, Teresa Stevie, Hollenhorst, Peter C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7485968/
https://www.ncbi.nlm.nih.gov/pubmed/32915889
http://dx.doi.org/10.1371/journal.pone.0238999

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7485968/
https://www.ncbi.nlm.nih.gov/pubmed/32915889
http://dx.doi.org/10.1371/journal.pone.0238999

Ejemplares similares