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A high-throughput screen identifies inhibitors of the interaction between the oncogenic transcription factor ERG and the cofactor EWS
Aberrant expression of the transcription factor ERG is a key driving event in approximately one-half of all of prostate cancers. Lacking an enzymatic pocket and mainly disordered, the structure of ERG is difficult to exploit for therapeutic design. We recently identified EWS as a specific interactin...
Autores principales: | Nicholas, Taylor R., Meng, Jingwei, Greulich, Benjamin M., Morris, Teresa Stevie, Hollenhorst, Peter C. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7485968/ https://www.ncbi.nlm.nih.gov/pubmed/32915889 http://dx.doi.org/10.1371/journal.pone.0238999 |
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