Computer-guided binding mode identification and affinity improvement of an LRR protein binder without structure determination

Precise binding mode identification and subsequent affinity improvement without structure determination remain a challenge in the development of therapeutic proteins. However, relevant experimental techniques are generally quite costly, and purely computational methods have been unreliable. Here, we...

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Detalles Bibliográficos
Autores principales: Choi, Yoonjoo, Jeong, Sukyo, Choi, Jung-Min, Ndong, Christian, Griswold, Karl E., Bailey-Kellogg, Chris, Kim, Hak-Sung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7485979/
https://www.ncbi.nlm.nih.gov/pubmed/32866140
http://dx.doi.org/10.1371/journal.pcbi.1008150

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7485979/
https://www.ncbi.nlm.nih.gov/pubmed/32866140
http://dx.doi.org/10.1371/journal.pcbi.1008150

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