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Computer-guided binding mode identification and affinity improvement of an LRR protein binder without structure determination
Precise binding mode identification and subsequent affinity improvement without structure determination remain a challenge in the development of therapeutic proteins. However, relevant experimental techniques are generally quite costly, and purely computational methods have been unreliable. Here, we...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7485979/ https://www.ncbi.nlm.nih.gov/pubmed/32866140 http://dx.doi.org/10.1371/journal.pcbi.1008150 |