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Rice stripe virus suppresses jasmonic acid-mediated resistance by hijacking brassinosteroid signaling pathway in rice
Rice stripe virus (RSV) is one of the most destructive viral diseases affecting rice production. However, so far, only one RSV resistance gene has been cloned, the molecular mechanisms underlying host-RSV interaction are still poorly understood. Here, we show that increasing levels or signaling of b...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7485985/ https://www.ncbi.nlm.nih.gov/pubmed/32866183 http://dx.doi.org/10.1371/journal.ppat.1008801 |
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author | Hu, Jinlong Huang, Jie Xu, Haosen Wang, Yongsheng Li, Chen Wen, Peizheng You, Xiaoman Zhang, Xiao Pan, Gen Li, Qi Zhang, Hongliang He, Jun Wu, Hongming Jiang, Ling Wang, Haiyang Liu, Yuqiang Wan, Jianmin |
author_facet | Hu, Jinlong Huang, Jie Xu, Haosen Wang, Yongsheng Li, Chen Wen, Peizheng You, Xiaoman Zhang, Xiao Pan, Gen Li, Qi Zhang, Hongliang He, Jun Wu, Hongming Jiang, Ling Wang, Haiyang Liu, Yuqiang Wan, Jianmin |
author_sort | Hu, Jinlong |
collection | PubMed |
description | Rice stripe virus (RSV) is one of the most destructive viral diseases affecting rice production. However, so far, only one RSV resistance gene has been cloned, the molecular mechanisms underlying host-RSV interaction are still poorly understood. Here, we show that increasing levels or signaling of brassinosteroids (BR) and jasmonic acid (JA) can significantly enhance the resistance against RSV. On the contrary, plants impaired in BR or JA signaling are more susceptible to RSV. Moreover, the enhancement of RSV resistance conferred by BR is impaired in OsMYC2 (a key positive regulator of JA response) knockout plants, suggesting that BR-mediated RSV resistance requires active JA pathway. In addition, we found that RSV infection suppresses the endogenous BR levels to increase the accumulation of OsGSK2, a key negative regulator of BR signaling. OsGSK2 physically interacts with OsMYC2, resulting in the degradation of OsMYC2 by phosphorylation and reduces JA-mediated defense to facilitate virus infection. These findings not only reveal a novel molecular mechanism mediating the crosstalk between BR and JA in response to virus infection and deepen our understanding about the interaction of virus and plants, but also suggest new effective means of breeding RSV resistant crops using genetic engineering. |
format | Online Article Text |
id | pubmed-7485985 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-74859852020-09-21 Rice stripe virus suppresses jasmonic acid-mediated resistance by hijacking brassinosteroid signaling pathway in rice Hu, Jinlong Huang, Jie Xu, Haosen Wang, Yongsheng Li, Chen Wen, Peizheng You, Xiaoman Zhang, Xiao Pan, Gen Li, Qi Zhang, Hongliang He, Jun Wu, Hongming Jiang, Ling Wang, Haiyang Liu, Yuqiang Wan, Jianmin PLoS Pathog Research Article Rice stripe virus (RSV) is one of the most destructive viral diseases affecting rice production. However, so far, only one RSV resistance gene has been cloned, the molecular mechanisms underlying host-RSV interaction are still poorly understood. Here, we show that increasing levels or signaling of brassinosteroids (BR) and jasmonic acid (JA) can significantly enhance the resistance against RSV. On the contrary, plants impaired in BR or JA signaling are more susceptible to RSV. Moreover, the enhancement of RSV resistance conferred by BR is impaired in OsMYC2 (a key positive regulator of JA response) knockout plants, suggesting that BR-mediated RSV resistance requires active JA pathway. In addition, we found that RSV infection suppresses the endogenous BR levels to increase the accumulation of OsGSK2, a key negative regulator of BR signaling. OsGSK2 physically interacts with OsMYC2, resulting in the degradation of OsMYC2 by phosphorylation and reduces JA-mediated defense to facilitate virus infection. These findings not only reveal a novel molecular mechanism mediating the crosstalk between BR and JA in response to virus infection and deepen our understanding about the interaction of virus and plants, but also suggest new effective means of breeding RSV resistant crops using genetic engineering. Public Library of Science 2020-08-31 /pmc/articles/PMC7485985/ /pubmed/32866183 http://dx.doi.org/10.1371/journal.ppat.1008801 Text en © 2020 Hu et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Hu, Jinlong Huang, Jie Xu, Haosen Wang, Yongsheng Li, Chen Wen, Peizheng You, Xiaoman Zhang, Xiao Pan, Gen Li, Qi Zhang, Hongliang He, Jun Wu, Hongming Jiang, Ling Wang, Haiyang Liu, Yuqiang Wan, Jianmin Rice stripe virus suppresses jasmonic acid-mediated resistance by hijacking brassinosteroid signaling pathway in rice |
title | Rice stripe virus suppresses jasmonic acid-mediated resistance by hijacking brassinosteroid signaling pathway in rice |
title_full | Rice stripe virus suppresses jasmonic acid-mediated resistance by hijacking brassinosteroid signaling pathway in rice |
title_fullStr | Rice stripe virus suppresses jasmonic acid-mediated resistance by hijacking brassinosteroid signaling pathway in rice |
title_full_unstemmed | Rice stripe virus suppresses jasmonic acid-mediated resistance by hijacking brassinosteroid signaling pathway in rice |
title_short | Rice stripe virus suppresses jasmonic acid-mediated resistance by hijacking brassinosteroid signaling pathway in rice |
title_sort | rice stripe virus suppresses jasmonic acid-mediated resistance by hijacking brassinosteroid signaling pathway in rice |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7485985/ https://www.ncbi.nlm.nih.gov/pubmed/32866183 http://dx.doi.org/10.1371/journal.ppat.1008801 |
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