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Molecular Biology and Epidemiology of Neurotropic Viruses

Neurotropic viruses are those viruses that can cause central nervous system (CNS) diseases with both neuroinvasive and neurovirulence properties. It comprises a wide range of viruses, including herpes simplex virus, poliovirus, enteroviruses, parechovirus, West Nile virus, Japanese encephalitis viru...

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Autores principales: Abdullahi, Abba Musa, Sarmast, Shah T, Singh, Romil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7485989/
https://www.ncbi.nlm.nih.gov/pubmed/32923269
http://dx.doi.org/10.7759/cureus.9674
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author Abdullahi, Abba Musa
Sarmast, Shah T
Singh, Romil
author_facet Abdullahi, Abba Musa
Sarmast, Shah T
Singh, Romil
author_sort Abdullahi, Abba Musa
collection PubMed
description Neurotropic viruses are those viruses that can cause central nervous system (CNS) diseases with both neuroinvasive and neurovirulence properties. It comprises a wide range of viruses, including herpes simplex virus, poliovirus, enteroviruses, parechovirus, West Nile virus, Japanese encephalitis virus, measles, and mumps viruses among others. Some of these viruses are highly neuroinvasive and neurovirulent, while others are weakly neuroinvasive and neurovirulent. Moreover, some of them, like herpes simplex viruses, are highly neuroinvasive but weakly neurovirulent for the peripheral nervous system and highly neurovirulent but weakly neuroinvasive for the central nervous system. All these disparities are a result of differences in their genomic constitution, associated vectors, geographical region, and environmental factors. Therefore, a successful intervention will be almost impossible without a clear understanding of the molecular biology and epidemiology of these viruses. Thus, we conducted a review of the published studies on the molecular biology and epidemiology of the common neurotropic viruses to make the viral genetic makeup more understandable for targeted intervention and provide the morbidity and mortality data of the different neurotropic viruses for more serious action.
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spelling pubmed-74859892020-09-12 Molecular Biology and Epidemiology of Neurotropic Viruses Abdullahi, Abba Musa Sarmast, Shah T Singh, Romil Cureus Neurology Neurotropic viruses are those viruses that can cause central nervous system (CNS) diseases with both neuroinvasive and neurovirulence properties. It comprises a wide range of viruses, including herpes simplex virus, poliovirus, enteroviruses, parechovirus, West Nile virus, Japanese encephalitis virus, measles, and mumps viruses among others. Some of these viruses are highly neuroinvasive and neurovirulent, while others are weakly neuroinvasive and neurovirulent. Moreover, some of them, like herpes simplex viruses, are highly neuroinvasive but weakly neurovirulent for the peripheral nervous system and highly neurovirulent but weakly neuroinvasive for the central nervous system. All these disparities are a result of differences in their genomic constitution, associated vectors, geographical region, and environmental factors. Therefore, a successful intervention will be almost impossible without a clear understanding of the molecular biology and epidemiology of these viruses. Thus, we conducted a review of the published studies on the molecular biology and epidemiology of the common neurotropic viruses to make the viral genetic makeup more understandable for targeted intervention and provide the morbidity and mortality data of the different neurotropic viruses for more serious action. Cureus 2020-08-11 /pmc/articles/PMC7485989/ /pubmed/32923269 http://dx.doi.org/10.7759/cureus.9674 Text en Copyright © 2020, Abdullahi et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Neurology
Abdullahi, Abba Musa
Sarmast, Shah T
Singh, Romil
Molecular Biology and Epidemiology of Neurotropic Viruses
title Molecular Biology and Epidemiology of Neurotropic Viruses
title_full Molecular Biology and Epidemiology of Neurotropic Viruses
title_fullStr Molecular Biology and Epidemiology of Neurotropic Viruses
title_full_unstemmed Molecular Biology and Epidemiology of Neurotropic Viruses
title_short Molecular Biology and Epidemiology of Neurotropic Viruses
title_sort molecular biology and epidemiology of neurotropic viruses
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7485989/
https://www.ncbi.nlm.nih.gov/pubmed/32923269
http://dx.doi.org/10.7759/cureus.9674
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