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Distinct phosphorylation sites in a prototypical GPCR differently orchestrate β-arrestin interaction, trafficking, and signaling
Agonist-induced phosphorylation of G protein–coupled receptors (GPCRs) is a key determinant for their interaction with β-arrestins (βarrs) and subsequent functional responses. Therefore, it is important to decipher the contribution and interplay of different receptor phosphorylation sites in governi...
Autores principales: | Dwivedi-Agnihotri, Hemlata, Chaturvedi, Madhu, Baidya, Mithu, Stepniewski, Tomasz Maciej, Pandey, Shubhi, Maharana, Jagannath, Srivastava, Ashish, Caengprasath, Natarin, Hanyaloglu, Aylin C., Selent, Jana, Shukla, Arun K. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486103/ https://www.ncbi.nlm.nih.gov/pubmed/32917711 http://dx.doi.org/10.1126/sciadv.abb8368 |
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